CBLB

Cbl proto-oncogene B, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.

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Products

Antibodies (18)

Type

Primary (18)

Target

CBLB (18)

Reactivity

Human (11)

Mouse (14)

Rat (2)

Application

IHC (5)

IHC-P (1)

WB (16)

DB (2)

ELISA (7)

IP (2)

Peptide-ELISA (1)

Host

rabbit (15)

mouse (3)

Product Group

IHCPlus (1)

Isotype

IgG (12)

IgG2a (3)

Clonality

monoclonal mc (3)

polyclonal pc (15)

Clone

246C5a (2)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

PE Conjugated (1)

Unconjugated (13)

Epitope

aa862-889 (7)

aa450-500 (1)

aa932-982 (1)

Publications

No (18)

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CBLB Antibody LS-C77365

Antibody:

CBLB Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$558

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CBLB Antibody LS-C806305

Antibody:

CBLB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

CBLB Antibody LS-C331824

Antibody:

CBLB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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CBLB Antibody (clone 246C5a) LS-C342566

Antibody:

CBLB Mouse anti-Human Monoclonal (246C5a) Antibody

Reactivity:

Mouse, Human

Applications:

DB, WB

Format:

Unconjugated

Price:

100 µg/$486

Select

CBLB Antibody (aa862-889) LS-C320019

Antibody:

CBLB Rabbit anti-Mouse Polyclonal (aa862-889) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

CBLB Antibody (aa862-889, Biotin) LS-C221663

Antibody:

CBLB Rabbit anti-Mouse Polyclonal (aa862-889) (Biotin) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

CBLB Antibody (aa862-889, FITC) LS-C221664

Antibody:

CBLB Rabbit anti-Mouse Polyclonal (aa862-889) (FITC) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

CBLB Antibody (aa862-889, APC) LS-C221662

Antibody:

CBLB Rabbit anti-Mouse Polyclonal (aa862-889) (APC) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

CBLB Antibody (aa862-889, Azide-free, HRP) LS-C221665

Antibody:

CBLB Rabbit anti-Mouse Polyclonal (aa862-889) (Azide-free) (HRP) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

CBLB Antibody (aa862-889, PE) LS-C221666

Antibody:

CBLB Rabbit anti-Mouse Polyclonal (aa862-889) (PE) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

IHC-plus™ CBLB Antibody (aa450-500) LS-B13486

(4.0) Rating

Antibody:

CBLB Rabbit anti-Human Polyclonal (aa450-500) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP

Format:

Unconjugated

Price:

50 µl/$460

Select

CBLB Antibody LS-C341405

Antibody:

CBLB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

Select

CBLB Antibody LS-C765140

Antibody:

CBLB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

CBLB Antibody LS-C778659

Antibody:

CBLB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

CBLB Antibody (clone 246C5a) LS-C184529

Antibody:

CBLB Mouse anti-Human Monoclonal (246C5a) Antibody

Reactivity:

Mouse, Human

Applications:

DB, WB

Format:

Unconjugated

Price:

100 µg/$965

Select

CBLB Antibody (aa932-982) LS-C289613

Antibody:

CBLB Rabbit anti-Human Polyclonal (aa932-982) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

CBLB Antibody (aa862-889) LS-C158182

Antibody:

CBLB Rabbit anti-Mouse Polyclonal (aa862-889) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

CBLB Antibody LS-C659672

Antibody:

CBLB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Format:

Unconjugated

Price:

100 µg/$331

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