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CBFB

core-binding factor, beta subunit

CBFB is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: core-binding factor, beta subunit
Synonyms: CBFB, CBF-beta, PEBP2-beta, PEA2-beta, PEBP2B
Target Sequences: NM_001755 NP_001746.1 Q13951

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Products
Proteins (11)
Over-Expression Lysate (4)
Recombinant (7)
CBFB (11)
No (11)
GST (1)
GST, N-terminus (1)
His (1)
His-SUMO (1)
His-T7 (2)
Myc-DDK (Flag) (5)
Human (8)
Mouse (1)
293T Cells (2)
E. coli (4)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Purified (2)
CBFB Protein - Purified recombinant protein CBFB was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
21.3 kDa
20 µg/$1,107
CBFB Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CBFB Protein - Recombinant  Core Binding Factor Beta Subunit By SDS-PAGE
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E. coli
His-T7
25.2 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
CBFB Protein - Recombinant Core Binding Factor Beta Subunit By SDS-PAGE
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E. coli
His-T7
25.7 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
CBFB Protein
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E. coli
His-SUMO
37.49 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CBFB Protein - 12.5% SDS-PAGE of human CBFB stained with Coomassie Blue
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Wheat Germ Extract
GST
45.76 kDa
10 µg/$479; 25 µg/$670
CBFB Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
21.3 kDa
100 µg/$494
CBFB Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
21.8 kDa
100 µg/$494
CBFB Protein
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E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261; 20 µg/$298; 100 µg/$473; 500 µg/$1,177
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293T Cells
Myc-DDK (Flag)
21.3 kDa
20 µg/$150
CBFB Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
21.8 kDa
20 µg/$150
Viewing 1-11 of 11 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).