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CBFA1 / RUNX2

runt-related transcription factor 2

Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.

Gene Name: runt-related transcription factor 2
Synonyms: RUNX2, AML3, CCD, CCD1, OSF2, PEBP2A1, PEBP2A2, PEA2-alpha A, PEBP2-alpha A, OSF-2, PEBP2A, PEBP2aA1, CBF-alpha-1, CBFA1, Oncogene AML-3, PEA2aA, PEBP2aA
Target Sequences: NM_004348 NP_004339.3 Q13950

Publications (2)

1
Hydrostatic pressure induces osteogenic differentiation of adipose-derived mesenchymal stem cells through increasing lncRNA-PAGBC. Jiangying Ru, Lieping Guo, Yinjun Ji, Yunfei Niu. Aging. 2020 July;12:13477-13487. [Full Text Article] [PubMed:32661199] [PMC:PMC7377829]
2
Tourniquet use following blast-associated complex lower limb injury and traumatic amputation promotes end organ dysfunction and amplified heterotopic ossification formation. Philip J Spreadborough, Amy L Strong, John Mares, Benjamin Levi, Thomas A Davis. Journal of orthopaedic surgery and research. 2022 September;17:422. [Full Text Article] [PubMed:36123728] [PMC:PMC9484189]

☰ Filters
Products
ELISA Kits (24)
Competitive EIA (2)
Custom (2)
Sandwich (17)
Sandwich CLIA (3)
CBFA1 / RUNX2 (24)
Human (6)
Mouse (6)
Rat (6)
Chicken (1)
Guinea pig (1)
Monkey (1)
Pig (1)
Rabbit (2)
12 x 8-Well Microstrips (2)
96-Well Microplate (5)
96-Well Strip Plate (17)
No (22)
Yes (2)
Cell Lysates (3)
Plasma (17)
Serum (17)
Tissue Homogenates (7)
CBFA1 / RUNX2 ELISA Kit
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Sandwich
96-Well Microplate
Rat
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CBFA1 / RUNX2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
CBFA1 / RUNX2 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$958
CBFA1 / RUNX2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
CBFA1 / RUNX2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CBFA1 / RUNX2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$818
CBFA1 / RUNX2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CBFA1 / RUNX2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CBFA1 / RUNX2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CBFA1 / RUNX2 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CBFA1 / RUNX2 ELISA Kit
Select
Sandwich
96-Well Microplate
Rabbit
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
CBFA1 / RUNX2 ELISA Kit
Select
Sandwich
96-Well Microplate
Pig
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
CBFA1 / RUNX2 ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
CBFA1 / RUNX2 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
CBFA1 / RUNX2 ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CBFA1 / RUNX2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CBFA1 / RUNX2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CBFA1 / RUNX2 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
CBFA1 / RUNX2 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
CBFA1 / RUNX2 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
CBFA1 / RUNX2 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Rat
2.5 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
CBFA1 / RUNX2 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Rat
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
CBFA1 / RUNX2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CBFA1 / RUNX2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).