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CAV1 / Caveolin 1

caveolin 1, caveolae protein, 22kDa

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.

Gene Name: caveolin 1, caveolae protein, 22kDa
Synonyms: CAV1, Caveolin-1, CGL3, CAV, MSTP085, VIP21, BSCL3
Target Sequences: NM_001753 NP_001744.2 Q03135

Publications (9)

1
Epithelial growth factor-induced phosphorylation of caveolin 1 at tyrosine 14 stimulates caveolae formation in epithelial cells. Orlichenko L, Huang B, Krueger E, McNiven MA. The Journal of biological chemistry. 2006 281:4570-9. [PubMed:16332692]
2
Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability. Catalucci D, Zhang DH, DeSantiago J, Aimond F, Barbara G, Chemin J, Bonci D, Picht E, Rusconi F, Dalton ND, Peterson KL, Richard S, Bers DM, Brown JH, Condorelli G. The Journal of cell biology. 2009 184:923-33. [PubMed:19307602] [PMC:PMC2699149]
3
Quantitative proteomics of caveolin-1-regulated proteins: characterization of polymerase i and transcript release factor/CAVIN-1 IN endothelial cells. Dvalos A, Fernndez-Hernando C, Sowa G, Derakhshan B, Lin MI, Lee JY, Zhao H, Luo R, Colangelo C, Sessa WC. Molecular & cellular proteomics : MCP. 2010 9:2109-24. [PubMed:20585024] [PMC:PMC2953909]
4
Functional heterogeneity of breast fibroblasts is defined by a prostaglandin secretory phenotype that promotes expansion of cancer-stem like cells. Rudnick JA, Arendt LM, Klebba I, Hinds JW, Iyer V, Gupta PB, Naber SP, Kuperwasser C. PloS one. 2011 6:e24605. [PubMed:21957456] [PMC:PMC3177828]
5
Matrix metalloproteinase-9 in homocysteine-induced intestinal microvascular endothelial paracellular and transcellular permeability. Munjal C, Tyagi N, Lominadze D, Tyagi SC. Journal of cellular biochemistry. 2012 113:1159-69. (ICC; Human) [PubMed:22275073] [PMC:PMC3337944]
6
AMP kinase activation improves angiogenesis in pulmonary artery endothelial cells with in utero pulmonary hypertension. Teng RJ, Du J, Afolayan AJ, Eis A, Shi Y, Konduri GG. American journal of physiology. Lung cellular and molecular physiology. 2013 304:L29-42. (WB; Sheep) [PubMed:23103561] [PMC:PMC3543642]
7
A Frame-Shift Mutation in CAV1 Is Associated with a Severe Neonatal Progeroid and Lipodystrophy Syndrome. Schrauwen I, Szelinger S, Siniard AL, Kurdoglu A, Corneveaux JJ, Malenica I, Richholt R, Van Camp G, De Both M, Swaminathan S, Turk M, Ramsey K, Craig DW, Narayanan V, Huentelman MJ. PloS one. 2015 10:e0131797. (WB; Human) [Full Text Article] [PubMed:26176221] [PMC:PMC4503302] Related Antibodies: LS-B192.
8
Ultrastructure and lipid composition of detergent-resistant membranes derived from mammalian sperm and two types of epithelial cells. van Gestel RA, Brouwers JF, Ultee A, Helms JB, Gadella BM. Cell and tissue research. 2016 363:129-45. (DB; Dog) [Full Text Article] [PubMed:26378009] [PMC:PMC4700079] Related Antibodies: LS-A2869.
9
Caveolin-1 selectively regulates microRNA sorting into microvesicles after noxious stimuli. Heedoo Lee, Chunhua Li, Yang Zhang, Duo Zhang, Leo E Otterbein, Yang Jin. The Journal of experimental medicine. 2019 September;216:2202-2220. [Full Text Article] [PubMed:31235510] [PMC:PMC6719430]
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ELISA Kits (33)
Cell-Based (1)
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CAV1 / Caveolin 1 (33)
Human (10)
Mouse (8)
Rat (8)
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Monkey (1)
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No (33)
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Ascites (2)
Cell Culture Supernatants (4)
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Plasma (22)
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CAV1 / Caveolin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CAV1 / Caveolin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CAV1 / Caveolin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
CAV1 / Caveolin 1 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
39.06 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CAV1 / Caveolin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
39.063 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
CAV1 / Caveolin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.234 - 15 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$764
CAV1 / Caveolin 1 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
CAV1 / Caveolin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$782
CAV1 / Caveolin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Ascites, Cell Culture Supernatants, Cerebrospinal Fluid, Plasma, Saliva, Serum, Tissue Homogenates, Urine
1 Plate/$913
CAV1 / Caveolin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Ascites, Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$1,041
CAV1 / Caveolin 1 ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
CAV1 / Caveolin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CAV1 / Caveolin 1 ELISA Kit
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Development Kit
Antibody Pair and Standard
Human
0.48 - 30 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
500 Wells/$1,182; 1000 Wells/$1,747
CAV1 / Caveolin 1 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
CAV1 / Caveolin 1 ELISA Kit
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Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$783
CAV1 / Caveolin 1 ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
CAV1 / Caveolin 1 ELISA Kit
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Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$929
CAV1 / Caveolin 1 ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
CAV1 / Caveolin 1 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
CAV1 / Caveolin 1 ELISA Kit
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Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$929
CAV1 / Caveolin 1 ELISA Kit
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Sandwich
96-Well Microplate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
CAV1 / Caveolin 1 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
12.5 - 800 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
CAV1 / Caveolin 1 ELISA Kit
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Sandwich
96-Well Microplate
Chicken
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
CAV1 / Caveolin 1 ELISA Kit
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Sandwich
96-Well Microplate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CAV1 / Caveolin 1 ELISA Kit
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Sandwich
96-Well Microplate
Rabbit
46.875 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).