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CATSPER3
cation channel, sperm associated 3
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
| Gene Name: | cation channel, sperm associated 3 |
| Family/Subfamily: | Ion Channel , Calcium channel - sperm associated |
| Synonyms: | CATSPER3, Ca(v)-like protein, CACRC, Putative ion channel CatSper3 |
| Target Sequences: | AX358304 CAD23320.1 Q86XQ3 |
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