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CAST / Calpastatin
Calpastatin
CAST / Calpastatin is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.
| Gene Name: | Calpastatin |
| Synonyms: | CAST, Calpastatin, BS-17, Calpain inhibitor, Sperm BS-17 component |
| Target Sequences: | NM_001750 NP_001741.4 P20810 |
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