CASR/Calcium Sensing Receptor

calcium-sensing receptor

CASR, a Calcium-Sensing Receptor, functions as a sensor in parathyroid and kidney to determine extracellular calcium concentration and to maintain calcium homeostasis. This receptor regulates both secretion of parathyroid hormone and excretion of urinary calcium. Mutations that inactivate CASR cause familial hypocalciuric hypercalcemia, which is also correlated with hyperparathyroidism. On the other hand, mutations that activate CASR cause autosomal dominant hypocalcemia. Hjalm et al. (2001) and Awata et al. (2001) have identified the binding of filamin-1 to the C-terminal tail of CASR, which may contribute to its localization in caveolae, link it to the actin-based cytoskeleton, and participate in CASR-mediated activation of MAPK. Multiple isoforms for CASR are produced by alternative splicing.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

CASR/Calcium Sensing Receptor (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (2)

His (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (2)

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Human CASR/Calcium Sensing Receptor Protein (Recombinant GST, N-terminus) (aa21-120) - LS-G57996

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CASR/Calcium Sensing Receptor Protein (Recombinant GST, N-terminus) (aa21-130) - LS-G57997

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CASR/Calcium Sensing Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75862

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

120.5 kDa

Price:

20 µg/$150

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Mouse CASR/Calcium Sensing Receptor Protein (Recombinant His) (aa863-1079) - LS-G24843

Source:

E. coli

Tag:

His

Molecular Weight:

27.5 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

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Human CASR/Calcium Sensing Receptor Protein (Recombinant GST) (aa20-612) - LS-G20562

Source:

E. coli

Tag:

GST

Molecular Weight:

93.8 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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CASR/Calcium Sensing Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99022

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

120.5 kDa

Price:

100 µg/$494

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