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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CASR/Calcium Sensing Receptor

calcium-sensing receptor

CASR, a Calcium-Sensing Receptor, functions as a sensor in parathyroid and kidney to determine extracellular calcium concentration and to maintain calcium homeostasis. This receptor regulates both secretion of parathyroid hormone and excretion of urinary calcium. Mutations that inactivate CASR cause familial hypocalciuric hypercalcemia, which is also correlated with hyperparathyroidism. On the other hand, mutations that activate CASR cause autosomal dominant hypocalcemia. Hjalm et al. (2001) and Awata et al. (2001) have identified the binding of filamin-1 to the C-terminal tail of CASR, which may contribute to its localization in caveolae, link it to the actin-based cytoskeleton, and participate in CASR-mediated activation of MAPK. Multiple isoforms for CASR are produced by alternative splicing.

Gene Name: calcium-sensing receptor
Family/Subfamily: GPCR , Calcium-sensing
Synonyms: CASR, Ca sensing receptor, Ca2+ sensing receptor, Calcium-sensing receptor, FIH, EIG8, GPRC2A, HHC, HHC1, Hypocalciuric hypercalcemia 1, PCAR1, NSHPT, CAR, FHH
Target Sequences: NM_000388 NP_000379.2 P41180

Publications (3)

1
The Ca2+-sensing receptor activates cytosolic phospholipase A2 via a Gqalpha -dependent ERK-independent pathway. Handlogten ME, Huang C, Shiraishi N, Awata H, Miller RT. The Journal of biological chemistry. 2001 276:13941-8. [PubMed:11278341]
2
Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein. Awata H, Huang C, Handlogten ME, Miller RT. The Journal of biological chemistry. 2001 276:34871-9. [PubMed:11390379]
3
Comparative expression of the extracellular calcium-sensing receptor in the mouse, rat, and human kidney. Graca JA, Schepelmann M, Brennan SC, Reens J, Chang W, Yan P, Toka H, Riccardi D, Price SA. American journal of physiology. Renal physiology. 2016 310:F518-33. (WB; Human) [Full Text Article] [PubMed:26661650] [PMC:PMC5005276] Related Antibodies: LS-C117834.

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Target
CASR/Calcium Sensing Receptor (94)
Reactivity
Human (77)
Mouse (45)
Rat (31)
Bat (8)
Bovine (16)
Chicken (8)
Dog (8)
Hamster (8)
Horse (8)
Monkey (9)
Pig (9)
Rabbit (13)
Application
IHC (40)
IHC-Fr (7)
IHC-P (36)
WB (68)
Flo (8)
ELISA (20)
ICC (7)
IF (24)
IP (5)
Peptide-ELISA (2)
RIA (5)
Host
rabbit (83)
mouse (11)
Isotype
IgG (27)
IgG1,k (5)
IgG2a (1)
IgG2a,k (1)
IgG2b (3)
Clonality
monoclonal mc (10)
polyclonal pc (84)
Clone
3F12 (1)
ADD (1)
HL 1499 (5)
Format
AP Conjugated (5)
APC (1)
APC Conjugated (6)
Atto 390 Conjugated (1)
Atto 488 Conjugated (1)
Atto 565 Conjugated (1)
Atto 594 Conjugated (2)
Atto 633 Conjugated (1)
Atto 655 Conjugated (1)
Atto 680 Conjugated (1)
Atto 700 Conjugated (1)
Azide-free (4)
Biotin Conjugated (8)
Cy3 Conjugated (1)
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Unconjugated (37)
Epitope
N-Terminus (27)
aa260-287 (8)
aa863-1079 (8)
pThr888 (5)
830-910 aa (2)
C-Terminus (2)
Ala884 (1)
aa214-235 (1)
aa854-903 (1)
Publications
No (93)
Yes (1)
Showing 1-25 of 94 results

IHC-plus™ CASR/Calcium Sensing Receptor Antibody (N-Terminus) LS-A1425
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CASR/Calcium Sensing Receptor antibody IHC of human kidney, diabetes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ CASR/Calcium Sensing Receptor Antibody (N-Terminus, clone HL 1499) LS-B78
Mouse Monoclonal [clone HL 1499] (IgG1,k) to Human CASR/Calcium Sensing Receptor
Rabbit, Mouse, Rat, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, IP, RIA, WB
Unconjugated
100µl 1mg/ml  $425.00
Anti-Calcium Sensing Receptor antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CASR/Calcium Sensing Receptor Antibody (N-Terminus, clone HL 1499, Biotin) LS-C140884
Mouse Monoclonal [clone HL 1499] (IgG1,k) to Human CASR/Calcium Sensing Receptor
Rabbit, Mouse, Rat, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, IP, RIA, WB
Biotin Conjugated
100µl  $365.00
Anti-Calcium Sensing Receptor antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of Calcium Sensing Receptor in transfected 293 cell lysate. ECL exposure, 5 minutes. In this photo, the protein has aggregated and thus the higher MW band as expected.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CASR/Calcium Sensing Receptor Antibody (N-Terminus, clone HL 1499, DY650) LS-C140885
Mouse Monoclonal [clone HL 1499] (IgG1,k) to Human CASR/Calcium Sensing Receptor
Rabbit, Mouse, Rat, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, IP, RIA, WB
DY650 Conjugated
100µl 0.95mg/ml  $365.00
Anti-Calcium Sensing Receptor antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of Calcium Sensing Receptor in transfected 293 cell lysate. ECL exposure, 5 minutes. In this photo, the protein has aggregated and thus the higher MW band as expected.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CASR/Calcium Sensing Receptor Antibody (N-Terminus, clone HL 1499, DY488) LS-C140886
Mouse Monoclonal [clone HL 1499] (IgG1,k) to Human CASR/Calcium Sensing Receptor
Rabbit, Mouse, Rat, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, IP, RIA, WB
DY488 Conjugated
100µl 0.7mg/ml  $365.00
Anti-Calcium Sensing Receptor antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of Calcium Sensing Receptor in transfected 293 cell lysate. ECL exposure, 5 minutes. In this photo, the protein has aggregated and thus the higher MW band as expected.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CASR/Calcium Sensing Receptor Antibody (N-Terminus, clone HL 1499, DY550) LS-C140888
Mouse Monoclonal [clone HL 1499] (IgG1,k) to Human CASR/Calcium Sensing Receptor
Rabbit, Mouse, Rat, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, IP, RIA, WB
DY550 Conjugated
100µl  $365.00
Anti-Calcium Sensing Receptor antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of Calcium Sensing Receptor in transfected 293 cell lysate. ECL exposure, 5 minutes. In this photo, the protein has aggregated and thus the higher MW band as expected.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

IHC-plus™ CASR/Calcium Sensing Receptor Antibody (N-Terminus) LS-A1427
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Human
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CASR/Calcium Sensing Receptor antibody IHC of human kidney, diabetes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ CASR/Calcium Sensing Receptor Antibody (N-Terminus, Biotin) LS-A101143
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Human
IHC, IHC-P
Biotin Conjugated
100µl  $650.00
Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CASR/Calcium Sensing Receptor antibody IHC of human kidney, diabetes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ CASR/Calcium Sensing Receptor Antibody (N-Terminus, FITC) LS-A101144
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Human
IHC, IHC-P
FITC Conjugated
100µl  $650.00
Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CASR/Calcium Sensing Receptor antibody IHC of human kidney, diabetes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ CASR/Calcium Sensing Receptor Antibody (N-Terminus, APC) LS-A101142
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Human
IHC, IHC-P
APC Conjugated
100µl  $650.00
Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CASR/Calcium Sensing Receptor antibody IHC of human kidney, diabetes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ CASR/Calcium Sensing Receptor Antibody (N-Terminus, Azide-free, HRP) LS-A101145
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl  $650.00
Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CASR/Calcium Sensing Receptor antibody IHC of human kidney, diabetes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ CASR/Calcium Sensing Receptor Antibody (N-Terminus, PE) LS-A101146
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Human
IHC, IHC-P
PE Conjugated
100µl  $650.00
Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CASR/Calcium Sensing Receptor antibody IHC of human kidney, diabetes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ CASR/Calcium Sensing Receptor Antibody (N-Terminus, AP) LS-A101141
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Human
IHC, IHC-P
AP Conjugated
100µl  $650.00
Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CASR/Calcium Sensing Receptor antibody IHC of human kidney, diabetes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ CASR/Calcium Sensing Receptor Antibody (aa214-235, clone ADD) LS-B7687
Mouse Monoclonal [clone ADD] (IgG2a) to Human CASR/Calcium Sensing Receptor
Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-Fr, IHC-P, WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-FIH / CASR antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.

CASR/Calcium Sensing Receptor Antibody (aa854-903) LS-C117834
Publications (1)
Publications (1)
Rabbit Polyclonal (IgG) to Human CASR/Calcium Sensing Receptor
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Calcium Sensing Receptor Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from LOVO cells, using Calcium Sensing Receptor Antibody. The lane on the right is blocked with the synthesized peptide.

IHC-plus™ CASR/Calcium Sensing Receptor Antibody (N-Terminus) LS-B2894
Rabbit Polyclonal to Rat CASR/Calcium Sensing Receptor
Rat, Human
IHC, IHC-P, WB
Unconjugated
250µl  $425.00
Anti-Calcium Sensing Receptor antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 15 ug/ml.
Anti-Calcium Sensing Receptor antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 15 ug/ml.

CASR/Calcium Sensing Receptor Antibody LS-C417520
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Mouse, Rat, Human
IHC, WB
Unconjugated
100µg  $305.00
Western blot of Calcium Sensing Receptor expression in LOVO whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

IHC-plus™ CASR/Calcium Sensing Receptor Antibody (N-Terminus) LS-A1426
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Bovine, Human
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

CASR/Calcium Sensing Receptor Antibody (C-Terminus) LS-C4299
Rabbit Polyclonal (IgG) to Human CASR/Calcium Sensing Receptor
Human
ELISA, IHC, WB
Unconjugated
100µl  $755.00

IHC-plus™ CASR/Calcium Sensing Receptor Antibody LS-B12064
Rabbit Polyclonal (IgG) to Human CASR/Calcium Sensing Receptor
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05mg 1mg/ml  $425.00
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)

CASR/Calcium Sensing Receptor Antibody LS-C808650
Rabbit Polyclonal (IgG) to Human CASR/Calcium Sensing Receptor
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Immunohistochemistry Image

CASR/Calcium Sensing Receptor Antibody LS-C96200
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Human
ELISA
Unconjugated
100µg 100µl  $345.00

CASR/Calcium Sensing Receptor Antibody LS-C756625
Mouse Monoclonal (IgG2b) to Human CASR/Calcium Sensing Receptor
Human
Flo, ICC, IHC-Fr, IHC-P, WB
Unconjugated
100µg  $355.00
Western blot analysis of CASR using anti-CASR antibody. Electrophoresis was performed on a 8% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions. Lane 1: human Hela whole cell lysate,Lane 2: human A549 whole cell lysate,Lane 3: human 22RV1 whole cell lysate,Lane 4: human HepG2 whole cell lysate,Lane 5: human Caco-2 whole cell lysate. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with mouse anti-CASR antigen affinity purified monoclonal antibody at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1% Tween 3 times with 5 minutes each and probed with a goat anti-mouse IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system.
Flow Cytometry analysis of NEURO-2A cells using anti-CASR antibody. Overlay histogram showing NEURO-2A cells stained with anti-CASR antibody (Blue line). The cells were blocked with 10% normal goat serum. And then incubated with mouse anti-CASR Antibody (1µg/10E6 cells) for 30 min at 20°C. DyLight®488 conjugated goat anti-mouse IgG (5-10µg/10E6 cells) was used as secondary antibody for 30 minutes at 20°C. Isotype control antibody (Green line) was mouse IgG (1µg/10E6 cells) used under the same conditions. Unlabelled sample (Red line) was also used as a control.

CASR/Calcium Sensing Receptor Antibody (phospho-Thr888) LS-C801089
Rabbit Polyclonal (IgG) to Human CASR/Calcium Sensing Receptor
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunofluorescence Image
Immunofluorescence Image

CASR/Calcium Sensing Receptor Antibody (phospho-Thr888) LS-C416670
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
100µg  $305.00
Western blot of Calcium Sensing Receptor phosphorylation expression in LOVO whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
Showing 1-25 of 94 results

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).