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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CASR/Calcium Sensing Receptor

calcium-sensing receptor

CASR, a Calcium-Sensing Receptor, functions as a sensor in parathyroid and kidney to determine extracellular calcium concentration and to maintain calcium homeostasis. This receptor regulates both secretion of parathyroid hormone and excretion of urinary calcium. Mutations that inactivate CASR cause familial hypocalciuric hypercalcemia, which is also correlated with hyperparathyroidism. On the other hand, mutations that activate CASR cause autosomal dominant hypocalcemia. Hjalm et al. (2001) and Awata et al. (2001) have identified the binding of filamin-1 to the C-terminal tail of CASR, which may contribute to its localization in caveolae, link it to the actin-based cytoskeleton, and participate in CASR-mediated activation of MAPK. Multiple isoforms for CASR are produced by alternative splicing.

Gene Name: calcium-sensing receptor
Family/Subfamily: GPCR , Calcium-sensing
Synonyms: CASR, Ca sensing receptor, Ca2+ sensing receptor, Calcium-sensing receptor, FIH, EIG8, GPRC2A, HHC, HHC1, Hypocalciuric hypercalcemia 1, PCAR1, NSHPT, CAR, FHH
Target Sequences: NM_000388 NP_000379.2 P41180

Publications (3)

1
The Ca2+-sensing receptor activates cytosolic phospholipase A2 via a Gqalpha -dependent ERK-independent pathway. Handlogten ME, Huang C, Shiraishi N, Awata H, Miller RT. The Journal of biological chemistry. 2001 276:13941-8. [PubMed:11278341]
2
Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein. Awata H, Huang C, Handlogten ME, Miller RT. The Journal of biological chemistry. 2001 276:34871-9. [PubMed:11390379]
3
Comparative expression of the extracellular calcium-sensing receptor in the mouse, rat, and human kidney. Graca JA, Schepelmann M, Brennan SC, Reens J, Chang W, Yan P, Toka H, Riccardi D, Price SA. American journal of physiology. Renal physiology. 2016 310:F518-33. (WB; Human) [Full Text Article] [PubMed:26661650] [PMC:PMC5005276] Related Antibodies: LS-C117834.


CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Human
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Human
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Human
IHC, IHC-P
FITC Conjugated
100µl   $650.00
CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Human
IHC, IHC-P
APC Conjugated
100µl   $650.00
CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Human
IHC, IHC-P
AP Conjugated
100µl   $650.00
CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Human
IHC, IHC-P
PE Conjugated
100µl   $650.00
CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl   $650.00
CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
APC Conjugated
100µl   $650.00
CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
AP Conjugated
100µl   $650.00
CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
PE Conjugated
100µl   $650.00
CASR/Calcium Sensing Receptor Antibody - Anti-Calcium Sensing Receptor antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Mouse Monoclonal [clone HL 1499] (IgG1,k) to Human CASR/Calcium Sensing Receptor
Rabbit, Mouse, Rat, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, IP, RIA, WB
Unconjugated
100µl   1mg/ml   $425.00
CASR/Calcium Sensing Receptor Antibody - Anti-FIH / CASR antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
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Mouse Monoclonal [clone ADD] (IgG2a) to Human CASR/Calcium Sensing Receptor
Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-Fr, IHC-P, WB
Unconjugated
50µg   1mg/ml   $425.00
CASR/Calcium Sensing Receptor Antibody - Anti-Calcium Sensing Receptor antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 15 ug/ml.
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Rabbit Polyclonal to Rat CASR/Calcium Sensing Receptor
Rat, Human
IHC, IHC-P, WB
Unconjugated
250µl   $425.00
CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Bovine, Human
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Bovine, Human
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Bovine, Human
IHC, IHC-P
FITC Conjugated
100µl   $650.00
CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Bovine, Human
IHC, IHC-P
APC Conjugated
100µl   $650.00
CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Bovine, Human
IHC, IHC-P
AP Conjugated
100µl   $650.00
CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Bovine, Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
CASR/Calcium Sensing Receptor Antibody - Anti-CASR antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human CASR/Calcium Sensing Receptor
Bovine, Human
IHC, IHC-P
PE Conjugated
100µl   $650.00
CASR/Calcium Sensing Receptor Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal (IgG) to Human CASR/Calcium Sensing Receptor
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).