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CASQ1 / Calsequestrin 1

calsequestrin 1 (fast-twitch, skeletal muscle)

Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca2+ ions. Regulates the release of lumenal Ca2+ via the calcium release channel RYR1; this plays an important role in triggering muscle contraction.

Gene Name:	calsequestrin 1 (fast-twitch, skeletal muscle)
Synonyms:	CASQ1, CASQ, Calsequestrin-1, Calmitine, PDIB1, Calmitin
Target Sequences:	NM_001231 NP_001222.3 P31415

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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