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CASP9 / Caspase 9

caspase 9, apoptosis-related cysteine peptidase

CASP9 / Caspase 9 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

Gene Name: caspase 9, apoptosis-related cysteine peptidase
Family/Subfamily: Protease , Cysteine C14
Synonyms: CASP9, APAF3, CASPASE-9c, ICE-LAP6, MCH6, ICE-like apoptotic protease 6, APAF-3, Apoptotic protease Mch-6, CASP-9, Caspase 9, Caspase-9, PPP1R56
Target Sequences: NM_001229 NP_001220.2 P55211

Publications (2)

1
Apocytochrome c blocks caspase-9 activation and Bax-induced apoptosis. Martin AG, Fearnhead HO. The Journal of biological chemistry. 2002 277:50834-41. [PubMed:12393884]
2
Caspase-9 acts as a regulator of necroptotic cell death10<sup> Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Hungary. Tamás Molnár , Petra Pallagi , Bálint Tél , Róbert Király, Eszter Csoma, Viktória Jenei, Zsófia Varga , Péter Gogolák, Anne Odile Hueber, Zoltán Máté, Ferenc Erdélyi, Gábor Szabó, Aladár Pettkó-Szandtner, Attila Bácsi, László Virág, József Maléth , Gábor Koncz. The Breast : official journal of the European Society of Mastology. 2021 Nov;;288:6476-6491. [Full Text Article] [PubMed:33899329] Related Antibodies: LS-C148248.

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Proteins (13)
Over-Expression Lysate (5)
Recombinant (8)
CASP9 / Caspase 9 (13)
No (13)
6His, N-terminus (1)
GST (1)
His (4)
His, N-Terminal (1)
His-GST (1)
Myc-DDK (Flag) (5)
Human (9)
Mouse (1)
Rat (1)
293T Cells (2)
E. coli (6)
HEK 293 Cells (4)
Wheat Germ Extract (1)
Purified (1)
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HEK 293 Cells
6His, N-terminus
48 kDa
100 µg/$288
CASP9 / Caspase 9 Protein - Recombinant  Caspase 9 By SDS-PAGE
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E. coli
His-GST
42.2 kDa
10 µg/$262; 50 µg/$370; 100 µg/$591; 200 µg/$736; 1 mg/$1,701; 500 µg/$1,274; 5 mg/$3,620
CASP9 / Caspase 9 Protein - Purified recombinant protein CASP9 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
30 kDa
20 µg/$1,005
CASP9 / Caspase 9 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
30 kDa
100 µg/$458
CASP9 / Caspase 9 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
46.1 kDa
100 µg/$458
CASP9 / Caspase 9 Protein - 12.5% SDS-PAGE of human CASP9 stained with Coomassie Blue
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Wheat Germ Extract
GST
71.5 kDa
10 µg/$469; 25 µg/$630
CASP9 / Caspase 9 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
46.1 kDa
20 µg/$130
CASP9 / Caspase 9 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
30 kDa
20 µg/$130
CASP9 / Caspase 9 Protein
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E. coli
His, N-Terminal
46.1 kDa
50 µg/$390
CASP9 / Caspase 9 Protein - Recombinant Caspase 9 By SDS-PAGE
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E. coli
His
16.9 kDa
10 µg/$262; 50 µg/$370; 100 µg/$591; 200 µg/$736; 1 mg/$1,701; 500 µg/$1,274; 5 mg/$3,620
CASP9 / Caspase 9 Protein - Recombinant Caspase 9 By SDS-PAGE
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E. coli
His
10.7 kDa
10 µg/$262; 50 µg/$370; 100 µg/$591; 200 µg/$736; 1 mg/$1,701; 500 µg/$1,274; 5 mg/$3,620
CASP9 / Caspase 9 Protein
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E. coli
His
23.4 kDa
10 µg/$268; 50 µg/$403; 100 µg/$641; 200 µg/$803; 1 mg/$1,814; 500 µg/$1,350; 5 mg/$3,902
CASP9 / Caspase 9 Protein
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E. coli
His
23.7 kDa
10 µg/$268; 50 µg/$403; 100 µg/$641; 200 µg/$803; 1 mg/$1,814; 500 µg/$1,350; 5 mg/$3,902
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).