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CASP8 / Caspase 8

caspase 8, apoptosis-related cysteine peptidase

Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.

Gene Name: caspase 8, apoptosis-related cysteine peptidase
Family/Subfamily: Protease , Cysteine C14
Synonyms: CASP8, ALPS2B, Apoptotic protease Mch-5, Apoptotic cysteine protease, Casp-8, Caspase-8, CAP4, Caspase 8, MACH, MCH5, MORT1-associated ced-3 homolog, ICE-like apoptotic protease 5, Pro Caspase 8, FADD-like ICE, FLICE, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein
Target Sequences: nm_001228 AAC50645.1 Q14790

Publications (2)

1
ARHGEF4 predicts poor prognosis and promotes cell invasion by influencing ERK1/2 and GSK-3a/ß signaling in pancreatic cancer. Keisuke Taniuchi, Mutsuo Furihata, Seiji Naganuma, Toshiji Saibara. International journal of oncology. 2018 Nov;53:2224-2240. [Full Text Article] [PubMed:30226582] Related Antibodies: LS-C344789.
2
BaxDelta2 promotes apoptosis through caspase-8 activation in microsatellite-unstable colon cancer. Zhang H, Lin Y, Ma[Character f1]as A, Zhao Y, Denning MF, Ma L, Xiang J. Molecular cancer research : MCR. 2014 Sep;12:1225-32. [Full Text Article] [PubMed:24842234] Related Antibodies: LS-C99287.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).