CASP8 / Caspase 8

caspase 8, apoptosis-related cysteine peptidase

Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.

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Products

ELISA Kits (29)

Type

Cell-Based (1)

Cell-Based Phosphorylation (2)

Custom (2)

Development Kit (2)

Sandwich (19)

Sandwich CLIA (3)

Target

CASP8 / Caspase 8 (29)

Reactivity

Human (15)

Mouse (7)

Rat (8)

Canine (1)

Pig (1)

Product Group

DevKit DuoPlus (2)

Format

12 x 8-Well Microstrips (3)

96-Well Microplate (7)

96-Well Strip Plate (17)

Antibody Pair and Standard (2)

Publications

No (29)

Sample Type

Adherent Cell Cultures (3)

Cell Culture Supernatants (6)

Cell Lysates (6)

Plasma (17)

Serum (19)

Tissue Homogenates (12)

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Human CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F11021

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$685

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Mouse CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F11020

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F51599

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum

Price:

1 Plate/$1,041

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Mouse/Human/Rat CASP8 / Caspase 8 (Cell-Based ELISA) ELISA Kit - LS-F1856

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Rat CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F4274

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$741

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Human CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F5366

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

1 Plate/$685

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Human CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F39693

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Serum

Price:

1 Plate/$1,150

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Human CASP8 / Caspase 8 (Custom ELISA) ELISA Kit - LS-F50241

Type:

Custom

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$700

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DevKit DuoPlus Human CASP8 / Caspase 8 ELISA Development Kit - LS-F71472

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Human

Range:

1.25 - 80 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

500 Wells/$1,089; 1000 Wells/$1,589

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DevKit DuoPlus Mouse CASP8 / Caspase 8 ELISA Development Kit - LS-F71489

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Mouse

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

500 Wells/$1,109; 1000 Wells/$1,625

Select

Canine CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F56402

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Canine

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F56377

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.031 - 2 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat CASP8 / Caspase 8 (Custom) ELISA Kit - LS-F66170

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Price:

1 Plate/$783

Select

Rat CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F21520

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Mouse CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F21298

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Human CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F20970

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Human CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F32783

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F32784

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F32785

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Pig CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F32786

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F31624

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Serum, Tissue Homogenates

Price:

1 Plate/$717

Select

Human CASP8 / Caspase 8 (CLIA) ELISA Kit - LS-F29519

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Mouse CASP8 / Caspase 8 (CLIA) ELISA Kit - LS-F30456

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Rat CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F27372

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.5 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

Select

Human CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F26737

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.5 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

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