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CASP6 / Caspase 6

caspase 6, apoptosis-related cysteine peptidase

Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-6 is an executioner caspase that was identified based on its homology with human caspases 2 and 3 as well as the C. elegans cell death protein CED-3. It possesses two isoforms, of which only the longer form possesses protease activity. Caspase-6 is highly expressed in adult brain and may play a role in several neuronal pathologies.

Gene Name: caspase 6, apoptosis-related cysteine peptidase
Family/Subfamily: Protease , Cysteine C14
Synonyms: CASP6, Apoptotic protease Mch-2, Caspase 6, CASP-6, Caspase-6, Mch-2, MCH2
Target Sequences: NM_001226 NP_001217.2 P55212

Publications (4)

1
Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment. LeBlanc AC, Ramcharitar J, Afonso V, Hamel E, Bennett DA, Pakavathkumar P, Albrecht S. Cell death and differentiation. 2014 21:696-706. (ICC; Human) [Full Text Article] [PubMed:24413155] [PMC:PMC3978300] Related Antibodies: LS-B477.
2
Resveratrol ameliorates oxidative stress and inhibits aquaporin 4 expression following rat cerebral ischemia-reperfusion injury. Li W, Tan C, Liu Y, Liu X, Wang X, Gui Y, Qin L, Deng F, Yu Z, Hu C, Chen L. Molecular medicine reports. 2015 November;12:7756-62. (Human) [Full Text Article] [PubMed:26458999]
3
Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice. Libin Zhou, Joseph Flores, Anastasia Noël, Olivier Beauchet, P Jesper Sjöström, Andrea C LeBlanc. Acta neuropathologica communications. 2019 Dec;7:210. [Full Text Article] [PubMed:31843022] [PMC:PMC6915996] Related Antibodies: LS-B477.
4
Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits. Anastasia Noël , Bénédicte Foveau , Andréa C LeBlanc. Cell death & disease. 2021 Mar;12:227. [Full Text Article] [PubMed:33649324] [PMC:PMC7921451] Related Antibodies: LS-B477.
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Proteins (9)
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CASP6 / Caspase 6 (9)
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CASP6 / Caspase 6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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22.4 kDa
100 µg/$494
CASP6 / Caspase 6 Protein
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33.1 kDa
50 µg/$419
CASP6 / Caspase 6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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Myc-DDK (Flag)
22.4 kDa
20 µg/$150
CASP6 / Caspase 6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
33.1 kDa
20 µg/$150
CASP6 / Caspase 6 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CASP6 / Caspase 6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
33.1 kDa
100 µg/$494
CASP6 / Caspase 6 Protein - Recombinant Caspase 6 By SDS-PAGE
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12.8 kDa
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CASP6 / Caspase 6 Protein - Recombinant Caspase 6 By SDS-PAGE
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).