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CASP5 / Caspase 5

caspase 5, apoptosis-related cysteine peptidase

CASP5 / Caspase 5 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.

Gene Name: caspase 5, apoptosis-related cysteine peptidase
Family/Subfamily: Protease , Cysteine C14
Synonyms: CASP5, CASP-5, Caspase 5, Caspase-5, ICE(rel)III, ICEREL-III, ICE(rel)-III, Ich-3, Protease TY, ICH3, Protease ICH-3, TY protease
Target Sequences: NM_004347 NP_004338.3 P51878

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Products
Proteins (9)
Over-Expression Lysate (4)
Recombinant (5)
CASP5 / Caspase 5 (9)
No (9)
6His, N-terminus (1)
GST, N-terminus (1)
His, N-Terminal (2)
His-SUMO (1)
Myc-DDK (Flag) (4)
Human (7)
293T Cells (2)
E. coli (3)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Yeast (1)
Purified (1)
CASP5 / Caspase 5 Protein
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E. coli
His, N-Terminal
47.7 kDa
50 µg/$419
CASP5 / Caspase 5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
43.1 kDa
100 µg/$494
CASP5 / Caspase 5 Protein
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E. coli
His-SUMO
37.81 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CASP5 / Caspase 5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
43.1 kDa
20 µg/$150
CASP5 / Caspase 5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
47.7 kDa
20 µg/$150
CASP5 / Caspase 5 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CASP5 / Caspase 5 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
100 µg/$446; 20 µg/$336; 1 mg/$1,460
CASP5 / Caspase 5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
47.7 kDa
100 µg/$494
CASP5 / Caspase 5 Protein - Recombinant Caspase 5 By SDS-PAGE
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E. coli
His, N-Terminal
24.5 kDa
10 µg/$277; 50 µg/$420; 100 µg/$670; 200 µg/$837; 1 mg/$1,928; 500 µg/$1,474; 5 mg/$2,927; 2 mg/$2,113
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).