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Locations
Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Telephone Numbers
Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
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Additional Contact Details
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CASP10 / Caspase 10
caspase 10, apoptosis-related cysteine peptidase
CASP10 / Caspase 10 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
| Gene Name: | caspase 10, apoptosis-related cysteine peptidase |
| Family/Subfamily: | Protease , Cysteine C14 |
| Synonyms: | CASP10, ALPS2, Caspase-10, Caspase 10, CASP-10, FADD-like ICE2, FLICE2, MCH4, ICE-like apoptotic protease 4, Apoptotic protease Mch-4 |
| Target Sequences: | NM_001230 NP_001221.2 Q92851 |
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