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CARS1 / CARS encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants.
Gene Name: | cysteinyl-tRNA synthetase |
Synonyms: | CARS, Cysteinyl-tRNA synthetase, CYSRS, Cysteine translase, CARS1, MGC:11246 |
Target Sequences: | NM_001751 NP_001742.1 P49589 |
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