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CARD14

caspase recruitment domain family, member 14

CARD14 is a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants.

Gene Name: caspase recruitment domain family, member 14
Synonyms: CARD14, BIMP2, Card-maguk protein 2, Carma 2, PrP, PSORS2, PSS1, CARMA2
Target Sequences: NM_024110 NP_077015.2 Q9BXL6

Publications (1)

1
Gain of function p.E138A alteration in Card14 leads to psoriasiform skin inflammation and implicates genetic modifiers in disease severity. John P Sundberg, C Herbert Pratt, Kathleen A Silva, Victoria E Kennedy, Wenning Qin, Timothy M Stearns, Jacqueline Frost, Beth A Sundberg, Anne M Bowcock. Experimental and molecular pathology. 2019 October;110:104286. [Full Text Article] [PubMed:31323190] [PMC:PMC7318844] Related Antibodies: LS-B11378.

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
CARD14 (6)
No (6)
GST (1)
GST, N-terminus (2)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (3)
Purified (1)
CARD14 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
113.1 kDa
100 µg/$710
CARD14 Protein - 12.5% SDS-PAGE of human CARD14 stained with Coomassie Blue
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Wheat Germ Extract
GST
74.9 kDa
10 µg/$479; 25 µg/$670
CARD14 Protein - Purified recombinant protein CARD14 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
113.1 kDa
20 µg/$1,107
CARD14 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
113.1 kDa
20 µg/$215
CARD14 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CARD14 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).