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Carboxypeptidase Z / CPZ
carboxypeptidase Z
The major form of CPZ mRNA in human salivary gland encodes a protein with an open reading frame of 641 amino acids. In addition, three variants were found that presumably arise due to alternative intron splicing. The 641 amino acid protein contains an 18 residue signal peptide-like sequence, a 120 residue region that shows 23-29% amino acid identity with a Cys-rich domain found in frizzled proteins and in type XVIII collagen, and then a 390 residue carboxypeptidase domain with 49% amino acid identity to carboxypeptidases E and N. The CPZ activity is more active at neutral pH than at pH 5.5 and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. CPZ is a metallocarboxypeptidase that is active toward substrates with C-terminal basic amino acids.
| Gene Name: | carboxypeptidase Z |
| Family/Subfamily: | Exopeptidase , Metallopeptidase M14 |
| Synonyms: | CPZ, Carboxypeptidase Z, Metallocarboxypeptidase Z |
| Target Sequences: | NM_003652 NP_003643.2 Q66K79 |
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