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Carboxylesterase 1 / CES1

carboxylesterase 1

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.

Gene Name: carboxylesterase 1
Synonyms: CES1, ACAT, Brain carboxylesterase hBr1, Carboxylesterase 1, Carboxylesterase 2 (liver), CEH, CES1A1, CES1A2, Cocaine carboxylesterase, Egasyn, HMSE, Liver carboxylesterase 1, HCE-1, PCE-1, Retinyl ester hydrolase, TGH, Triacylglycerol hydrolase, REH, SES1, CE-1, Cholesteryl ester hydrolase, HMSE1, Serine esterase 1
Target Sequences: L07764 AAA16036.1 P23141

Publications (1)

1
The targeted histone deacetylase inhibitor tefinostat (CHR-2845) shows selective in vitro efficacy in monocytoid-lineage leukaemias. Zabkiewicz J, Gilmour M, Hills R, Vyas P, Bone E, Davidson A, Burnett A, Knapper S. Oncotarget. 2016 7:16650-62. (WB; Human) [Full Text Article] [PubMed:26934551] [PMC:PMC4941341]

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Products
Proteins (15)
Over-Expression Lysate (6)
Recombinant (9)
Carboxylesterase 1 / CES1 (15)
No (15)
6His, C-terminus (2)
GST (1)
His, N-Terminal (2)
His-T7, N-terminus (1)
Myc-DDK (Flag) (9)
Human (10)
Mouse (1)
Rat (1)
293T Cells (3)
E. coli (3)
HEK 293 Cells (6)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (2)
Carboxylesterase 1 / CES1 Protein - Recombinant Carboxylesterase 1 By SDS-PAGE
Select
E. coli
His, N-Terminal
34.1 kDa
10 µg/$283; 50 µg/$452; 200 µg/$902; 1 mg/$2,016; 5 mg/$3,151; 2 mg/$2,204
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
61.05kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
Carboxylesterase 1 / CES1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
62.27 kDa
100 µg/$494
Carboxylesterase 1 / CES1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
62.59 kDa
100 µg/$710
Carboxylesterase 1 / CES1 Protein - Recombinant Carboxylesterase 1 (CES1) by SDS-PAGE
Select
E. coli
His-T7, N-terminus
31.5kDa
10 µg/$283; 50 µg/$452; 200 µg/$902; 100 µg/$722; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,601
Select
293T Cells
Myc-DDK (Flag)
62.27 kDa
20 µg/$150
Carboxylesterase 1 / CES1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
62.39 kDa
20 µg/$150
Carboxylesterase 1 / CES1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
62.59 kDa
20 µg/$215
Carboxylesterase 1 / CES1 Protein - Recombinant Carboxylesterase 1 By SDS-PAGE
Select
E. coli
His, N-Terminal
34.0 kDa
10 µg/$278; 50 µg/$422; 200 µg/$842; 1 mg/$1,934; 5 mg/$2,941; 2 mg/$2,119
Carboxylesterase 1 / CES1 Protein - 12.5% SDS-PAGE of human CES1 stained with Coomassie Blue
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Wheat Germ Extract
GST
87.78 kDa
10 µg/$479; 25 µg/$670
Carboxylesterase 1 / CES1 Protein - Purified recombinant protein CES1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
60.6 kDa
20 µg/$1,107
Carboxylesterase 1 / CES1 Protein - Purified recombinant protein CES1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
60.5 kDa
20 µg/$1,107
Carboxylesterase 1 / CES1 Protein - Purified recombinant protein CES1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
60.4 kDa
20 µg/$1,107
Carboxylesterase 1 / CES1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
62.39 kDa
100 µg/$494
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
61.1 kDa
10 µg/$344; 50 µg/$584
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).