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CAPN1 / Calpain 1

calpain 1, (mu/I) large subunit

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene.

Gene Name: calpain 1, (mu/I) large subunit
Family/Subfamily: Protease , Cysteine C2
Synonyms: CAPN1, Calpain i, Calpain mu-type, Calpain, large polypeptide L1, Calpain-1 catalytic subunit, Calpain 1, Calpain-1 large subunit, CANP, CANP1, Mu CANP, Mu-calpain, Mu-type calpain, MuCANP, Micromolar-calpain, MuCL, CANP 1, CANPL1
Target Sequences: BC008751 AAH08751.1 P07384

Publications (1)

1
Calpain-2 as a therapeutic target in repeated concussion-induced neuropathy and behavioral impairment. Yubin Wang, Yan Liu, Amy Nham, Arash Sherbaf, Diana Quach, Emad Yahya, Davis Ranburger, Xiaoning Bi, Michel Baudry. Science advances. 2020 July;6: [Full Text Article] [PubMed:32937436] [PMC:PMC7458466] Related Antibodies: LS-B4768.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).