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CAMLG / CAML
calcium modulating ligand
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.
| Gene Name: | calcium modulating ligand |
| Synonyms: | CAMLG, Calcium modulating ligand, CAML, Cyclophilin B-binding protein |
| Target Sequences: | NM_001745 NP_001736.1 P49069 |
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