CAMK4 / CaMK IV

calcium/calmodulin-dependent protein kinase IV

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.

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Products

Proteins (10)

Type

Over-Expression Lysate (2)

Recombinant (8)

Target

CAMK4 / CaMK IV (10)

Publications

No (10)

Tag

GST (1)

GST, N-terminus (2)

His (2)

His-GST (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Mouse (2)

Rat (1)

Source

293T Cells (1)

Baculovirus (2)

E. coli (2)

HEK 293 Cells (2)

Insect Cells (1)

Wheat Germ Extract (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (3)

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Human CAMK4 / CaMK IV Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65129

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.7 kDa

Price:

20 µg/$1,107

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Human CAMK4 / CaMK IV Protein (Recombinant GST, N-terminus) (aa364-473) - LS-G57967

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CAMK4 / CaMK IV Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74923

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.7 kDa

Price:

20 µg/$150

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Rat CAMK4 / CaMK IV Protein (Recombinant His) (Full Length) - LS-G20553

Source:

E. coli

Tag:

His

Molecular Weight:

57.2 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human CAMK4 / CaMK IV Protein (Recombinant GST) (Full Length) - LS-G27727

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

77.66 kDa

Price:

10 µg/$479; 25 µg/$670

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CAMK4 / CaMK IV Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99546

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.7 kDa

Price:

100 µg/$494

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Human CAMK4 / CaMK IV Protein (Recombinant GST, N-terminus) (Met1-Tyr473) - LS-G139931

Source:

Insect Cells

Tag:

GST, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

79 kDa

Price:

50 µg/$502

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Human CAMK4 / CaMK IV Protein (Recombinant His) - LS-G1600

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Mouse CAMK4 / CaMK IV Protein (Recombinant) (Met1-Tyr469) - LS-G98070

Source:

Baculovirus

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

52.7 kDa

Price:

50 µg/$625

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Mouse CAMK4 / CaMK IV Protein (Recombinant His-GST) (Met1-Tyr469) - LS-G98713

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

80.4 kDa

Price:

50 µg/$502

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