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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CAMK1 / CAMKI

calcium/calmodulin-dependent protein kinase I

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca2+ elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K+ and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.

Gene Name: calcium/calmodulin-dependent protein kinase I
Family/Subfamily: Protein Kinase , CAMK1
Synonyms: CAMK1, CaM kinase I, CaM-KI, CAMKI, CaM kinase I alpha, CaMKI-alpha
Target Sequences: NM_003656 NP_003647.1 Q14012

Filtered By: None
Target
CAMK1 / CAMKI (45)
Reactivity
Human (44)
Mouse (22)
Rat (22)
Bat (4)
Chimpanzee (3)
Guinea pig (4)
Horse (4)
Monkey (4)
Orangutan (3)
Pig (4)
Primate (7)
Rabbit (4)
Application
IHC (25)
IHC-P (5)
WB (38)
ELISA (25)
ICC (1)
IF (6)
IP (1)
Peptide-ELISA (2)
Host
rabbit (37)
mouse (8)
Isotype
IgG (20)
IgG1,k (7)
Clonality
monoclonal mc (8)
polyclonal pc (37)
Format
AP Conjugated (2)
APC (1)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (5)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (3)
Unconjugated (20)
Epitope
aa341-370 (8)
aa21-70 (4)
120-200 aa (2)
pThr177 (2)
C-Terminus (1)
Ser173 (1)
aa143-192 (1)
aa271-370 (1)
aa271-371 (1)
Publications
No (45)
Showing 1-25 of 45 results

CAMK1 / CAMKI Antibody (phospho-Thr177) LS-C198718
Rabbit Polyclonal (IgG) to Human CAMK1 / CAMKI
Mouse, Rat, Human
IF IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using CaMK1-alpha (Phospho-Thr177) Antibody. The picture on the right is blocked with the phospho peptide.
Immunofluorescence analysis of HeLa cells, using CaMK1-alpha (Phospho-Thr177) Antibody. The picture on the right is blocked with the phospho peptide.
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using CaMK1-alpha (Phospho-Thr177) Antibody. The picture on the right is blocked with the phospho peptide.
Immunofluorescence analysis of HeLa cells, using CaMK1-alpha (Phospho-Thr177) Antibody. The picture on the right is blocked with the phospho peptide.

CAMK1 / CAMKI Antibody (aa341-370) LS-C100731
Rabbit Polyclonal to Human CAMK1 / CAMKI
Mouse, Rat, Primate, Human
IHC IHC-P WB
Unconjugated
400µl  $305.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of CAMK1 (arrow) using rabbit polyclonal CAMK1 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CAMK1 gene (Lane 2) (Origene Technologies).
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of CAMK1 (arrow) using rabbit polyclonal CAMK1 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CAMK1 gene (Lane 2) (Origene Technologies).

CAMK1 / CAMKI Antibody (aa271-370) LS-C125236
Mouse Monoclonal (IgG) to Human CAMK1 / CAMKI
Human
ELISA WB
Unconjugated
100µg 1mg/ml  $590.00

CAMK1 / CAMKI Antibody (phospho-Thr177) LS-C354567
Rabbit Polyclonal to Human CAMK1 / CAMKI
Mouse, Rat, Human
ICC IF IHC IHC-P WB
Unconjugated
100µl 1mg/ml  $265.00
Immunohistochemical analysis of CaMK1 alpha (pT177) staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX. w
Immunofluorescent analysis of CaMK1 alpha (pT177) staining in Jurkat cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Immunohistochemical analysis of CaMK1 alpha (pT177) staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX. w
Immunofluorescent analysis of CaMK1 alpha (pT177) staining in Jurkat cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

CAMK1 / CAMKI Antibody (120-200 aa) LS-C381500
Rabbit Polyclonal (IgG) to Human CAMK1 / CAMKI
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
100µl 1mg/ml  $265.00

CAMK1 / CAMKI Antibody LS-C412670
Rabbit Polyclonal to Human CAMK1 / CAMKI
Mouse, Rat, Human
IF IHC WB
Unconjugated
100µl  $385.00

CAMK1 / CAMKI Antibody LS-C346186
Rabbit Polyclonal (IgG) to Human CAMK1 / CAMKI
Mouse, Rat, Human
IF IHC WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunofluorescence analysis of U20S cell using CAMK1 antibody. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of U20S cell using CAMK1 antibody. Blue: DAPI for nuclear staining.

CAMK1 / CAMKI Antibody (aa143-192) LS-C117836
Rabbit Polyclonal (IgG) to Human CAMK1 / CAMKI
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using CaMK1-alpha Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from COLO cells, using CaMK1-alpha Antibody. The lane on the right is blocked with the synthesized peptide.
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using CaMK1-alpha Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from COLO cells, using CaMK1-alpha Antibody. The lane on the right is blocked with the synthesized peptide.

CAMK1 / CAMKI Antibody (120-200 aa) LS-C382417
Rabbit Polyclonal (IgG) to Human CAMK1 / CAMKI
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00

CAMK1 / CAMKI Antibody LS-C500740
Rabbit Polyclonal (IgG) to Human CAMK1 / CAMKI
Mouse, Rat, Human
ELISA IF WB
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunofluorescent analysis of Hela cells using CAMK1 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Positive WB detected in:Rat brain tissue,Mouse brain tissue;All lanes:CAMK1 antibody at 3?g/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 42 KDa;Observed band size: 42 KDa;
Immunofluorescent analysis of Hela cells using CAMK1 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Positive WB detected in:Rat brain tissue,Mouse brain tissue;All lanes:CAMK1 antibody at 3?g/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 42 KDa;Observed band size: 42 KDa;

CAMK1 / CAMKI Antibody (Ser173) LS-C191912
Rabbit Polyclonal to Human CAMK1 / CAMKI
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
100µl  $345.00
Immunohistochemistry (IHC) analysis of CaMKI alpha (S173) pAb in paraffin-embedded human breast cancer tissue.
Immunohistochemistry (IHC) analysis of CaMKI alpha (S173) pAb in paraffin-embedded human breast cancer tissue.

CAMK1 / CAMKI Antibody (aa341-370, Biotin) LS-C218726
Rabbit Polyclonal (IgG) to Human CAMK1 / CAMKI
Mouse, Rat, Primate, Human
ELISA IHC WB
Biotin Conjugated
200µl  $680.00

CAMK1 / CAMKI Antibody (aa341-370, FITC) LS-C218727
Rabbit Polyclonal (IgG) to Human CAMK1 / CAMKI
Mouse, Rat, Primate, Human
ELISA IHC WB
FITC Conjugated
200µl  $680.00

CAMK1 / CAMKI Antibody (aa341-370, APC) LS-C218725
Rabbit Polyclonal (IgG) to Human CAMK1 / CAMKI
Mouse, Rat, Primate, Human
ELISA IHC WB
APC Conjugated
200µl  $680.00

CAMK1 / CAMKI Antibody (aa341-370, Azide-free, HRP) LS-C218728
Rabbit Polyclonal (IgG) to Human CAMK1 / CAMKI
Mouse, Rat, Primate, Human
ELISA IHC WB
HRP Conjugated, Azide-free
200µl  $680.00

CAMK1 / CAMKI Antibody (aa341-370, PE) LS-C218730
Rabbit Polyclonal (IgG) to Human CAMK1 / CAMKI
Mouse, Rat, Primate, Human
ELISA IHC WB
PE Conjugated
200µl  $680.00

CAMK1 / CAMKI Antibody (aa341-370, AP) LS-C218724
Rabbit Polyclonal (IgG) to Human CAMK1 / CAMKI
Mouse, Rat, Primate, Human
ELISA IHC WB
AP Conjugated
200µl  $680.00

CAMK1 / CAMKI Antibody LS-C400617
Rabbit Polyclonal (IgG) to Human CAMK1 / CAMKI
Mouse, Rat, Human
ELISA IHC
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human tonsil using CAMK1 Polyclonal Antibody at dilution of 1:10.
Immunohistochemistry of Human tonsil using CAMK1 Polyclonal Antibody at dilution of 1:10.

CAMK1 / CAMKI Antibody (C-Terminus) LS-C137148
Rabbit Polyclonal (IgG) to Human CAMK1 / CAMKI
Human
ELISA IHC
Unconjugated
100µl  $255.00
Immunohistochemistry Image
Immunohistochemistry Image

CAMK1 / CAMKI Antibody LS-C483895
Rabbit Polyclonal to Human CAMK1 / CAMKI
Human
ELISA IP WB
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00

CAMK1 / CAMKI Antibody (aa271-371) LS-C306711
Mouse Monoclonal (IgG1,k) to Human CAMK1 / CAMKI
Human
ELISA WB
Unconjugated
100µg  $560.00

CAMK1 / CAMKI Antibody (HRP) LS-C541217
Mouse Monoclonal (IgG1,k) to Human CAMK1 / CAMKI
Human
ELISA WB
HRP Conjugated
100µl  $710.00

CAMK1 / CAMKI Antibody (AP) LS-C503161
Mouse Monoclonal (IgG1,k) to Human CAMK1 / CAMKI
Human
ELISA WB
AP Conjugated
100µl  $710.00

CAMK1 / CAMKI Antibody (PE) LS-C649330
Mouse Monoclonal (IgG1,k) to Human CAMK1 / CAMKI
Human
ELISA WB
PE Conjugated
100µl  $710.00

CAMK1 / CAMKI Antibody LS-C663299
Rabbit Polyclonal to Human CAMK1 / CAMKI
Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $530.00; 10ml 0.5mg/ml  $2,100.00
DAB staining on fromalin fixed paraffin- embedded kidney tissue
Western Blot; Sample: Recombinant protein.
DAB staining on fromalin fixed paraffin- embedded kidney tissue
Western Blot; Sample: Recombinant protein.
Showing 1-25 of 45 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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