CALR / Calreticulin

calreticulin

Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.

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Products

Proteins (18)

Type

Over-Expression Lysate (2)

Recombinant (16)

Target

CALR / Calreticulin (18)

Publications

No (18)

Tag

6His, N-terminus (3)

Fc (1)

GST (2)

GST, N-terminus (2)

His (5)

His, N-Terminal (1)

His,C-terminus (1)

Myc-DDK (Flag) (3)

Species

Entamoeba histolytica (1)

Human (12)

Mouse (3)

Pig (1)

Source

293F Cells (1)

293T Cells (1)

E. coli (9)

HEK 293 Cells (4)

Wheat Germ Extract (1)

Yeast (2)

Purification

Purified (8)

Low Endotoxin Level

Low endotoxin level (3)

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Mouse CALR / Calreticulin Protein (Recombinant 6His, N-terminus) (aa18-416) - LS-G22837

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

48.3 kD

Price:

100 µg/$499; 20 µg/$364; 1 mg/$1,683

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Human CALR / Calreticulin Protein (Recombinant Fc) (Met1-Ala413) - LS-G97217

Source:

HEK 293 Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

73 kDa

Price:

50 µg/$721

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Mouse CALR / Calreticulin Protein (Recombinant His) (aa199-308) - LS-G13907

Source:

E. coli

Tag:

His

Molecular Weight:

16.1 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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CALR / Calreticulin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100268

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.14 kDa

Price:

100 µg/$494

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Human CALR / Calreticulin Protein (Recombinant His) (aa18-417) - LS-G3822

Source:

E. coli

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

~55kDa (SDS-PAGE)

Price:

50 µg/$564; 10 µg/$351

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Human CALR / Calreticulin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65144

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.4 kDa

Price:

20 µg/$1,107

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Human CALR / Calreticulin Protein (Recombinant His) (aa18-417) - LS-G773

Source:

E. coli

Tag:

His

Molecular Weight:

48.7 kDa

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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Human CALR / Calreticulin Protein (Recombinant GST, N-terminus) (Full Length) - LS-G136977

Source:

E. coli

Tag:

GST, N-terminus

Molecular Weight:

73.5 kDa

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human CALR / Calreticulin Protein (Recombinant His, N-Terminal) - LS-G132934

Source:

293F Cells

Tag:

His, N-Terminal

Molecular Weight:

60kDa

Price:

10 µg/$315; 50 µg/$652; 200 µg/$1,228; 100 µg/$1,034; 1 mg/$2,469; 500 µg/$1,971; 5 mg/$4,551; 2 mg/$2,661

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Mouse CALR / Calreticulin Protein (Recombinant GST) (aa18-416) - LS-G20551

Source:

E. coli

Tag:

GST

Molecular Weight:

73.7 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human CALR / Calreticulin Protein (Recombinant GST) (Full Length) - LS-G27724

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

71.61 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CALR / Calreticulin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74947

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.14 kDa

Price:

20 µg/$150

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Human CALR / Calreticulin Protein (Recombinant 6His, N-terminus) (aa18-417) - LS-G56132

Source:

E. coli

Tag:

6His, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Entamoeba histolytica CALR / Calreticulin Protein (Recombinant GST, N-terminus) - LS-G56134

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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Pig CALR / Calreticulin Protein (Recombinant 6His, N-terminus) (aa18-417) - LS-G57131

Source:

Yeast

Tag:

6His, N-terminus

Price:

1 mg/$1,973; 100 µg/$679; 20 µg/$429

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Human CALR / Calreticulin Protein (Recombinant His,C-terminus) (Met1-Ala413) - LS-G140721

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

47.4 kDa

Price:

50 µg/$721

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Human CALR / Calreticulin Protein (Recombinant His) (aa18-193) - LS-G13903

Source:

E. coli

Tag:

His

Molecular Weight:

21.6 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human CALR / Calreticulin Protein (Recombinant His) (aa196-310) - LS-G13906

Source:

E. coli

Tag:

His

Molecular Weight:

15.2 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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