CALHM1

calcium homeostasis modulator 1

Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca2+ concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca2+, Na+ and K+, as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca2+ dependent manner.

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Proteins (2)

Type

Over-Expression Lysate (2)

Target

CALHM1 (2)

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No (2)

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Myc-DDK (Flag) (2)

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Human (1)

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293T Cells (1)

HEK 293 Cells (1)

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CALHM1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122812

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.1 kDa

Price:

100 µg/$494

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Human CALHM1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G93554

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.1 kDa

Price:

20 µg/$150

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