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CADPS
Ca++-dependent secretion activator
Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca2+-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca2+ triggering.
| Gene Name: | Ca++-dependent secretion activator |
| Synonyms: | CADPS, CAPS-1, CAPS1, CADPS1, KIAA1121 |
| Target Sequences: | NM_003716 NP_003707.2 Q9ULU8 |
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