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CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms.
| Gene Name: | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase |
| Family/Subfamily: | Protease , Metallopeptidase M38 |
| Synonyms: | CAD, CAD trifunctional protein, DFF-40, DFF40, CAD protein, CPAN, DFF2 |
| Target Sequences: | NM_004341 NP_004332.2 P27708 |
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