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CAD

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Family/Subfamily: Protease , Metallopeptidase M38
Synonyms: CAD, CAD trifunctional protein, DFF-40, DFF40, CAD protein, CPAN, DFF2
Target Sequences: NM_004341 NP_004332.2 P27708

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Products
Antibodies (39)
Primary (39)
CAD (39)
Human (39)
Mouse (18)
Rat (8)
Bat (6)
Bovine (6)
Chimpanzee (6)
Dog (6)
Gibbon (6)
Guinea pig (3)
Hamster (6)
Horse (6)
Monkey (3)
Rabbit (3)
Zebrafish (3)
IHC (27)
IHC-P (11)
WB (30)
Flo (7)
ELISA (14)
IF (1)
IP (2)
Peptide-ELISA (2)
rabbit (35)
mouse (4)
Product Group
IHCPlus (4)
IgG (32)
IgG1 (4)
monoclonal mc (4)
polyclonal pc (35)
OTI10A3 (2)
OTI1A7 (2)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
Carrier-free (2)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (28)
aa780-809 (7)
N-Terminus (4)
aa1918-2225 (4)
aa2018-2067 (4)
400-480 aa (2)
aa1650-1700 (2)
pThr456 (2)
Ab-456 (1)
Ser1859 (1)
aa150-200 (1)
aa1850-2000 (1)
aa422-471 (1)
No (39)
CAD Antibody - CAD Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human breast carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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CAD Rabbit anti-Human Polyclonal (aa780-809) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
CAD Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CAD Rabbit anti-Human Polyclonal (aa1850-2000) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
CAD Antibody - Anti-CAD antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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CAD Rabbit anti-Human Polyclonal (aa1650-1700) Antibody
Human
IF, IHC, IHC-P
Unconjugated
50 µl/$460
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CAD Rabbit anti-Human Polyclonal (aa780-809) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
Select
CAD Rabbit anti-Human Polyclonal (aa780-809) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
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CAD Rabbit anti-Human Polyclonal (aa780-809) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
Select
CAD Rabbit anti-Human Polyclonal (aa780-809) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
Select
CAD Rabbit anti-Human Polyclonal (aa780-809) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
Select
CAD Rabbit anti-Human Polyclonal (aa780-809) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
CAD Antibody - Anti-CAD antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CAD Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
CAD Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CAD Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
CAD Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CAD Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Horse, Bat, Gibbon, Chimpanzee, Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
CAD Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CAD Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Horse, Bat, Gibbon, Chimpanzee, Human
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
CAD Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CAD Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Horse, Bat, Gibbon, Chimpanzee, Human
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
Select
CAD Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
CAD Antibody - Immunohistochemistry of paraffin-embedded human liver tissue.
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CAD Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
CAD Antibody - Detection of Human CAD by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-CAD used at a dilution of 1:200 (1 ug/ml).
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CAD Rabbit anti-Human Polyclonal (aa150-200) Antibody
Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
CAD Antibody - Detection of Human CAD by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-CAD used at a dilution of 1:200 (1 ug/ml).
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CAD Rabbit anti-Human Polyclonal (aa1650-1700) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
10 µl/$295; 100 µl/$514
Select
CAD Rabbit anti-Human Polyclonal (400-480 aa) Antibody
Mouse, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Select
CAD Rabbit anti-Human Polyclonal (400-480 aa) Antibody
Mouse, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CAD Antibody - Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using CAD Antibody. The picture on the right is blocked with the synthesized peptide.
Select
CAD Rabbit anti-Human Polyclonal (aa422-471) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
CAD Antibody - Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using CAD (Phospho-Thr456) Antibody. The picture on the right is blocked with the phospho peptide.
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CAD Rabbit anti-Human Polyclonal (pThr456) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
Select
CAD Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
CAD Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using CAD antibody.
Select
CAD Rabbit anti-Human Polyclonal (Ab-456) Antibody
Mouse, Human
ELISA, IHC
Unconjugated
100 µg/$357
CAD Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue  using CAD Polyclonal Antibody at dilution of 1:50(×200)
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CAD Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).