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CACNB4

calcium channel, voltage-dependent, beta 4 subunit

CACNB4 is a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: calcium channel, voltage-dependent, beta 4 subunit
Family/Subfamily: Ion Channel , Calcium channel - beta subunit
Synonyms: CACNB4, CAB4, Calcium channel beta 4, Cavbeta4, Cchb4, EA5, EJM6, EJM, CACNLB4, EIG9, EJM4
Target Sequences: NM_000726 NP_000717.2 O00305

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Products
Proteins (11)
Over-Expression Lysate (8)
Recombinant (3)
CACNB4 (11)
No (11)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (9)
Human (7)
293T Cells (4)
HEK 293 Cells (5)
Wheat Germ Extract (2)
Purified (1)
CACNB4 Protein - Purified recombinant protein CACNB4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
58 kDa
20 µg/$1,107
CACNB4 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CACNB4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
58 kDa
20 µg/$150
CACNB4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
56.2 kDa
20 µg/$215
CACNB4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
54.5 kDa
20 µg/$215
CACNB4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
51.2 kDa
20 µg/$150
CACNB4 Protein - 12.5% SDS-PAGE of human CACNB4 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
84.6 kDa
10 µg/$479; 25 µg/$670
CACNB4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
51.2 kDa
100 µg/$494
CACNB4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
58 kDa
100 µg/$494
CACNB4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
56.2 kDa
100 µg/$710
CACNB4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
54.5 kDa
100 µg/$710
Viewing 1-11 of 11 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).