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CACNA1S / Cav1.1

calcium channel, voltage-dependent, L type, alpha 1S subunit

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.

Gene Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Family/Subfamily: Ion Channel , Calcium channel - alpha subunit Cav1
Synonyms: CACNA1S, Alpha 1S, Cav1.1, CACNL1A3, CACN1, CCHL1A3, DHPR alpha 1S, Dihydropyridine receptor, HOKPP1, HypoPP, MHS5, HOKPP, TTPP1, CACH1
Target Sequences: NM_000069 AAA51902.1 Q13698

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Products
Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
CACNA1S / Cav1.1 (6)
No (6)
GST, N-terminus (1)
His, N-Terminal (2)
His-S (1)
Myc-DDK (Flag) (2)
Human (3)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (3)
HEK 293 Cells (1)
Wheat Germ Extract (1)
CACNA1S / Cav1.1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
212.2 kDa
100 µg/$710
CACNA1S / Cav1.1 Protein - Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit By SDS-PAGE
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E. coli
His-S
23.7 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
CACNA1S / Cav1.1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
212.2 kDa
20 µg/$215
CACNA1S / Cav1.1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CACNA1S / Cav1.1 Protein - Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) by SDS-PAGE
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E. coli
His, N-Terminal
26.8kDa
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
CACNA1S / Cav1.1 Protein - Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) by SDS-PAGE
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E. coli
His, N-Terminal
27.6kDa
10 µg/$273; 50 µg/$392; 200 µg/$782; 100 µg/$625; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).