CACNA1C / Cav1.2

calcium channel, voltage-dependent, L type, alpha 1C subunit

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.

☰ Filters

Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

CACNA1C / Cav1.2 (4)

Publications

No (4)

Tag

GST, N-terminus (1)

His-S (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Mouse (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Select

CACNA1C / Cav1.2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123019

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

239.5 kDa

Price:

100 µg/$710

Select

Mouse CACNA1C / Cav1.2 Protein (Recombinant His-S) (aa1978-2139) - LS-G25573

Source:

E. coli

Tag:

His-S

Molecular Weight:

24.5 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

Select

Human CACNA1C / Cav1.2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75508

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

239.5 kDa

Price:

20 µg/$215

Select

Human CACNA1C / Cav1.2 Protein (Recombinant GST, N-terminus) (aa2039-2138) - LS-G57956

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Viewing 1-4 of 4 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.