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CACNA1B / Cav2.2

calcium channel, voltage-dependent, N type, alpha 1B subunit

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

Gene Name:	calcium channel, voltage-dependent, N type, alpha 1B subunit
Family/Subfamily:	Ion Channel , Calcium channel - alpha subunit Cav2
Synonyms:	CACNA1B, Alpha 1b, BIII, Brain calcium channel III, Calcium channel, N type, Cav2.2, CACNN, CACH5, CACNL1A5
Target Sequences:	NM_000718 NP_000709.1 Q00975

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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