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CA8 / Carbonic Anhydrase VIII
carbonic anhydrase VIII
CA8 / Carbonic Anhydrase VIII was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form.
| Gene Name: | carbonic anhydrase VIII |
| Synonyms: | CA8, Carbonate dehydratase, CAMRQ3, CALS, CA-related protein, CA-VIII, Carbonic anhydrase VIII, CARP |
| Target Sequences: | NM_004056 NP_004047.3 P35219 |
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