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CA2 / Carbonic Anhydrase II

carbonic anhydrase II

Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.

Gene Name:	carbonic anhydrase II
Synonyms:	CA2, CA-II, CAII, CAC, Car2, Carbonate dehydratase II, Carbonic anhydrase C, Carbonic anhydrase II, Carbonic dehydratase, Carbonic anhydrase 2, Carbonic anhydrase B
Target Sequences:	NM_000067 NP_000058.1 P00918

Publications (6)

Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger. Li X, Alvarez B, Casey JR, Reithmeier RA, Fliegel L. The Journal of biological chemistry. 2002 277:36085-91. [PubMed:12138085]

Inhibition of cell growth and nuclear factor-kappaB activity in pancreatic cancer cell lines by a tylophorine analogue, DCB-3503. Shiah HS, Gao W, Baker DC, Cheng YC. Molecular cancer therapeutics. 2006 5:2484-93. [PubMed:17041092]

Catalysis and pH control by membrane-associated carbonic anhydrase IX in MDA-MB-231 breast cancer cells. Li Y, Tu C, Wang H, Silverman DN, Frost SC. The Journal of biological chemistry. 2011 286:15789-96. [PubMed:21454639] [PMC:PMC3091188]

Role of zinc in catalytic activity of carbonic anhydrase IX. Tu C, Foster L, Alvarado A, McKenna R, Silverman DN, Frost SC. Archives of biochemistry and biophysics. 2012 521:90-4. (WB; Human) [PubMed:22465027] [PMC:PMC3345035]

Loss of carbonic anhydrase XII function in individuals with elevated sweat chloride concentration and pulmonary airway disease. Melissa Lee, Briana Vecchio-Pagán, Neeraj Sharma, Abdul Waheed, Xiaopeng Li, Karen S Raraigh, Sarah Robbins, Sangwoo T Han, Arianna L Franca, Matthew J Pellicore, Taylor A Evans, Kristin M Arcara, Hien Nguyen, Shan Luan, Deborah Belchis, Jozef Hertecant, Joseph Zabner, William S Sly, Garry R Cutting. Human molecular genetics. 2016 May;25:1923-1933. [Full Text Article] [PubMed:26911677] [PMC:PMC5062583]

Quantitative Secretome Analysis Reveals Clinical Values of Carbonic Anhydrase II in Hepatocellular Carcinoma. Xiaohua Xing, Hui Yuan, Hongzhi Liu, Xionghong Tan, Bixing Zhao, Yingchao Wang, Jiahe Ouyang, Minjie Lin, Xiaolong Liu, Aimin Huang. Genomics, proteomics & bioinformatics. 2021 Feb;;19:94-107. [Full Text Article] [PubMed:33662630] [PMC:PMC8498920]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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