C6orf150 / MB21D1

Mab-21 domain containing 1

Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

C6orf150 / MB21D1 (7)

Publications

No (7)

Tag

6His-SUMO, N-terminus (1)

GST, N-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Human (5)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Mouse C6orf150 / MB21D1 Protein (Recombinant His-T7) (aa211-395) - LS-G26309

Source:

E. coli

Tag:

His-T7

Molecular Weight:

24.9kd

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human C6orf150 / MB21D1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72814

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.6 kDa

Price:

20 µg/$1,107

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Human C6orf150 / MB21D1 Protein (Recombinant 6His-SUMO, N-terminus) (aa161-522) - LS-G57556

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human C6orf150 / MB21D1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G93638

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.6 kDa

Price:

20 µg/$215

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C6orf150 / MB21D1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107402

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.6 kDa

Price:

100 µg/$710

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Human C6orf150 / MB21D1 Protein (Recombinant His-T7) (aa225-407) - LS-G26308

Source:

E. coli

Tag:

His-T7

Molecular Weight:

23.6 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human C6orf150 / MB21D1 Protein (Recombinant GST, N-terminus) (Full Length) - LS-G36210

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Molecular Weight:

83.9 kDa

Price:

2 µg/$439

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