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C5b-9 Terminal Complement Complex / TCC

The membrane attack complex (MAC) or terminal complement complex (TCC) is a structure typically formed on the surface of pathogenic bacterial cells as a result of the activation of the host's alternative pathway, classical pathway, or lectin pathway of the complement system, and it is one of the effector proteins of the immune system. The membrane-attack complex (MAC) forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-6-7 complex. The C5b-6-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-6-7-8 complex. C5b-6-7-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}.

C5b-9 Terminal Complement Complex / TCC Target Details

Target Name: C5b-9 Terminal Complement Complex / TCC

Publications (2)

1
Hematoma Changes During Clot Resolution After Experimental Intracerebral Hemorrhage. Cao S, Zheng M, Hua Y, Chen G, Keep RF, Xi G. Stroke; a journal of cerebral circulation. 2016 June;47:1626-31. [Full Text Article] [PubMed:27125525] [PMC:PMC5237112]
2
A fully recombinant human IgG1 Fc multimer (GL-2045) inhibits complement-mediated cytotoxicity and induces iC3b. Zhou H, Olsen H, So E, Mérigeon E, Rybin D, Owens J, LaRosa G, Block DS, Strome SE, Zhang X. Blood Advances. 2017 1:504-515. (IHC; Human) [Full Text Article] [PubMed:29296968] Related Antibodies: LS-C539399.

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C5b-9 Terminal Complement Complex / TCC (13)
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C5b-9 Terminal Complement Complex / TCC ELISA Kit
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96-Well Strip Plate
Rat
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
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1 Plate/$861
C5b-9 Terminal Complement Complex / TCC ELISA Kit
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96-Well Strip Plate
Mouse
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
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1 Plate/$834
C5b-9 Terminal Complement Complex / TCC ELISA Kit
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96-Well Strip Plate
Human
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
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1 Plate/$821
C5b-9 Terminal Complement Complex / TCC ELISA Kit
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96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Tissue Homogenates
1 Plate/$884
C5b-9 Terminal Complement Complex / TCC ELISA Kit
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96-Well Microplate
Rat
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$693
C5b-9 Terminal Complement Complex / TCC ELISA Kit
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96-Well Microplate
Mouse
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$693
C5b-9 Terminal Complement Complex / TCC ELISA Kit
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96-Well Strip Plate
Pig
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Tissue Homogenates
1 Plate/$917
C5b-9 Terminal Complement Complex / TCC ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
0.94 - 60 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$861
C5b-9 Terminal Complement Complex / TCC ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$948
C5b-9 Terminal Complement Complex / TCC ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$776
C5b-9 Terminal Complement Complex / TCC ELISA Kit
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96-Well Strip Plate
Human
12.5 - 800 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$869
C5b-9 Terminal Complement Complex / TCC ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$744
C5b-9 Terminal Complement Complex / TCC ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$744
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).