C5AR2 / GPR77 / C5L2 is a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants.
|Gene Name:||complement component 5a receptor 2|
|Family/Subfamily:||GPCR , Anaphylatoxin|
|Synonyms:||C5AR2, G-protein coupled receptor 77, GPF77, GPR77, C5L2, G protein-coupled receptor 77|
|Target Sequences:||NM_018485 NP_060955.1 Q9P296|
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