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C3AR / C3a Receptor

complement component 3a receptor 1

The C3a Anaphylatoxin Receptor mediates the effects of the inflammatory mediator anaphylatoxin C3a, which is released during complement activation. This receptor stimulates chemotaxis, granule enzyme release, and superoxide anion production. It also regulates glial cell activation, may be involved in the pathogenesis of asthma, and may promote cell repair.

Gene Name:	complement component 3a receptor 1
Family/Subfamily:	GPCR , Anaphylatoxin
Synonyms:	C3AR1, AZ3B, C3AR, C3R1, C3a receptor, C3a-R, HNFAG09, Anaphylatoxin c3a receptor, C3a anaphylatoxin receptor
Target Sequences:	NM_004054 NP_004045.1 Q16581

Publications (1)

C3a receptor blockade protects podocytes from injury in diabetic nephropathy. Marina Morigi, Luca Perico, Daniela Corna, Monica Locatelli, Paola Cassis, Claudia Elisa Carminati, Silvia Bolognini, Carlamaria Zoja, Giuseppe Remuzzi, Ariela Benigni, Simona Buelli. JCI insight. 2020 Mar;5:e131849. [Full Text Article] [PubMed:32161193] [PMC:PMC7141402] Related Antibodies: LS-C382362.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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