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C1orf190
leucine rich adaptor protein 1
Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway. In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella.
| Gene Name: | leucine rich adaptor protein 1 |
| Synonyms: | LURAP1, C1orf190, Leucine rich adaptor protein 1, LRAP35a, LRP35A, NF-kappa-B activator C1orf190 |
| Target Sequences: | NP_001013633.1 Q96LR2 |
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