C14orf169 / NO66

chromosome 14 open reading frame 169

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation By similarity. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

C14orf169 / NO66 (3)

Publications

No (3)

Tag

GST (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human C14orf169 / NO66 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91789

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.1 kDa

Price:

20 µg/$150

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Human C14orf169 / NO66 Protein (Recombinant GST) (Full Length) - LS-G35249

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

97.5 kDa

Price:

2 µg/$439

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C14orf169 / NO66 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109785

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.1 kDa

Price:

100 µg/$494

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