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C11 / POLR3K
polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
| Gene Name: | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa |
| Synonyms: | POLR3K, C11-RNP3, My010, HRPC11, RNA polymerase III subunit C10, RNA polymerase III subunit C11, RPC11, RPC12.5, C11, HsC11p, RNA polymerase III subunit CII, RPC10 |
| Target Sequences: | NM_016310 NP_057394.3 Q9Y2Y1 |
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