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Unfortunately, the antibody (ID:156224) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



c-Met

met proto-oncogene

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells.Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.

Gene Name: met proto-oncogene
Family/Subfamily: Protein Kinase , HGF Receptor/MET
Synonyms: MET, AUTS9, C-Met, HGF/SF receptor, HGFR, Met kinase, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, HGF receptor, RCCP2, Tyrosine-protein kinase Met
Target Sequences: NM_000245 NP_000236.2 P08581

Publications (3)

1
Pleomorphic phenotypes of gastrointestinal stromal tumors at metastatic sites with or without imatinib treatment. Sakamoto K, Sakurai S, Kanda T, Sakuma Y, Hishima T, Hironaka M, Bamba T, Keira Y, Takano Y, Niki T, Hasegawa T, Hirota S. Cancer science. 2010 101:1270-8. (IHC) [PubMed:20180814]
2
Receptor-type protein tyrosine phosphatase beta (RPTP-beta) directly dephosphorylates and regulates hepatocyte growth factor receptor (HGFR/Met) function. Xu Y, Xia W, Baker D, Zhou J, Cha HC, Voorhees JJ, Fisher GJ. The Journal of biological chemistry. 2011 286:15980-8. [PubMed:21454675] [PMC:PMC3091207] Related Antibodies: LS-C96910.
3
Met Signaling Cascade Is Amplified by the Recruitment of Phosphorylated Met to Lipid Rafts via CD24 and Leads to Drug Resistance in Endometrial Cancer Cell Lines. Ono YJ, Tanabe A, Tanaka T, Tanaka Y, Hayashi M, Terai Y, Ohmichi M. Molecular cancer therapeutics. 2015 14:2353-63. (ICC; Human) [Full Text Article] [PubMed:26227486]

Filtered By: None
Target
c-met (228)
Reactivity
Human (209)
Mouse (117)
Rat (47)
Bat (3)
Bovine (4)
Chicken (2)
Cynomolgus (1)
Dog (11)
Guinea pig (3)
Horse (3)
Monkey (5)
Pig (4)
Rabbit (7)
Sheep (4)
Xenopus (1)
Application
IHC (60)
IHC-Fr (1)
IHC-P (15)
WB (184)
Flo (11)
DB (8)
ELISA (116)
ICC (6)
IF (24)
IP (12)
Peptide-ELISA (7)
Host
rabbit (156)
mouse (71)
sheep (1)
Isotype
IgG (108)
IgG1 (54)
IgG2a (3)
IgG2b (2)
Clonality
monoclonal mc (75)
polyclonal pc (153)
Clone
18A5 (1)
1A8 (1)
1E6 (1)
2B5 (1)
2H2 (1)
3G5 (1)
4AT247 (1)
4AT259 (1)
4AT44 (1)
5E9B7 (1)
5E9C4 (1)
6AT1785 (1)
6AT1877 (1)
6AT203 (1)
6AT44.279 (7)
SP59 (1)
Format
Agarose Conjugated (1)
AP Conjugated (14)
APC Conjugated (16)
Azide-free (11)
Biotin Conjugated (17)
FITC Conjugated (18)
HRP Conjugated (16)
PE Conjugated (16)
Unconjugated (130)
Epitope
pTyr1349 (17)
pTyr1234/Tyr1235 (11)
pTyr1356 (10)
pTyr1234 (9)
pTyr1003 (7)
C-Terminus (6)
pTyr1235 (4)
aa1092-1379 (3)
aa125-421 (3)
aa570-885 (3)
Tyr1003 (2)
Tyr1234/Tyr1235 (2)
pTyr1230/Tyr1234/Tyr1235 (2)
Asp1228 (1)
Cytoplasmic Domain (1)
Glu999 (1)
Internal (1)
Thr1343 (1)
Tyr1234 (1)
aa1001-1005 (1)
aa1170-1250 (1)
aa1201-1250 (1)
aa1231-1240 (1)
aa1232-1236 (1)
aa1250-1330 (1)
aa1290-1370 (1)
aa1316-1365 (1)
aa1361-1379 (1)
aa208-407 (1)
aa250-330 (1)
aa276-325 (1)
aa586-601 (1)
aa950-1030 (1)
aa976-1025 (1)
pTyr1230 (1)
pTyr1349/Tyr1356 (1)
pTyr1365 (1)
Publications
No (227)
Yes (1)
Showing 1-25 out of 228 results
Anti-c-Met Antibody (Cytoplasmic Domain) IHC-plus™ LS-B2812
Anti-c-Met antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2812 concentration 10 ug/ml.

Mouse Monoclonal (IgG2a) to Human c-Met
Human
IHC IHC-Fr IHC-P
Unconjugated
Anti-c-Met Antibody (C-Terminus) IHC-plus™ LS-B3345
Anti-c-Met antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3345 concentration 15 ug/ml.
Anti-c-Met antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3345 concentration 15 ug/ml.

Rabbit Polyclonal to Human c-Met
Human
IHC IHC-P
Unconjugated
Anti-c-Met Antibody (clone 6AT1785) LS-C96427

Mouse Monoclonal [clone 6AT1785] (IgG1) to Human c-Met
Mouse, Human
IF IHC IHC-P WB
Unconjugated
Anti-c-Met Antibody (clone 6AT203) LS-C96426
MET/HGFR Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human hepatocarcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
Detection of endogenous Met in HepG2 cell line. 10 ug/lane of HepG2 cell lysate was used to examine the expression of human Met. Lanes 1-5 represent different anti-Met monoclonal antibodies. Lane 6 represents auto-phosphorylated-Met in HepG2 cell line detected by anti-phospho-Met antibody.

Mouse Monoclonal [clone 6AT203] (IgG1) to Human c-Met
Mouse, Human
IF IHC IHC-P WB
Unconjugated
Anti-c-Met Antibody (clone 4AT44) IHC-plus™ LS-B6889
Anti-c-Met antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6889 concentration 10 ug/ml.
Western blot of lysates from HeLa, HepG2, COS-7 cell line (from left to right), using MET/HGFR Antibody(4AT44). 4AT44 was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L (HRP) at 1:3000 dilution was used as the secondary antibody. Lysates at 35ug per lane.

Mouse Monoclonal [clone 4AT44] (IgG1) to Human c-Met
Mouse, Human
IF IHC IHC-P WB
Unconjugated
Anti-c-Met Antibody (phospho-Tyr1349/Tyr1356) LS-C60102
Anti-c-Met pY1349pY1356 Antibody - Western Blot. Western blot of affinity purified anti-c-Met pY1349pY1356 antibody shows detection of phosphorylated c-Met. Human mammary B5/589 epithelial cells were serum-deprived and treated with or without HGF. Cell lysates were immunoprecipitated with the anti-c-Met antibody, resolved by SDS-PAGE, transferred to PVDF membrane, and probed with anti-c-Met pY1349pY1356. Personal communication, D. Bottaro and T. Ito, NCI, Bethesda, MD.
Anti-c-Met pY1349pY1356 Antibody - Western Blot. Western blot of affinity purified anti-c-Met pY1349pY1356 antibody shows detection of phosphorylated c-Met. Human mammary epithelial cells (B5/589) were serum deprived and stimulated with (+) and without (-) HGF. Cell lysates were immunoprecipitated using a human anti-c-Met antibody, resolved by SDS-PAGE, transferred to PVDF membrane and probed using various antibodies. Lane 1 and 2 where probed using the anti-c-Met pY1349pY1356 antibody (#LS-C60102), lane 3 and 4 where probed using an anti-phosphotyrosine antibody as phosphorylation control and lane 5 and 6 where probed using an anti-cMet antibody as a total Met loading control. Bands recognized at an apparent molecular weight of ~170 kD are total Met, ~145 kD phosphorylated Met beta chain in HGF +, ~150 kD phosphorylated Met in +/- HGF, ~50kD phosphorylated Met alpha chain. Personal communication with D. Bottaro and F. Cecchi, CCR-NCI, Bethesda, MD.

Rabbit Polyclonal to Human c-Met
Mouse, Rat, Human
ELISA WB
Unconjugated
Anti-c-Met Antibody (phospho-Tyr1356) LS-C96910
Dot blot of anti-Phospho-MET-pY1356 Phospho-specific antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

Rabbit Polyclonal to Human c-Met
Human
DB
Unconjugated
Anti-c-Met Antibody (Tyr1234, Azide-free) LS-C72459

Mouse Monoclonal (IgG1) to Human c-Met
Mouse, Rat, Human
ELISA IP WB
Unconjugated, Azide-free
Anti-c-Met Antibody (aa1316-1365) IHC-plus™ LS-B8031
Anti-c-Met antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8031 dilution 10 ug/ml.
Anti-c-Met antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8031 dilution 10 ug/ml.

Rabbit Polyclonal (IgG) to Human c-Met
Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
Anti-c-Met Antibody (phospho-Tyr1349) LS-C96909
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
The anti-MET-Y1349 antibody is used in Western blot to detect MET-Y1349 in mouse kidney tissue lysate.

Rabbit Polyclonal to Human c-Met
Human
IHC IHC-P WB
Unconjugated
Anti-c-Met Antibody (aa250-330) LS-C384550

Rabbit Polyclonal (IgG) to Human c-Met
Human
ELISA IF
Unconjugated
Anti-c-Met Antibody (clone 5E9C4) LS-C682401
Immunofluorescence analysis of Hela cells using MET mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher
Immunohistochemical analysis of paraffin-embedded endometrial cancer tissues using MET mouse mAb with DAB staining.

Mouse Monoclonal [clone 5E9C4] (IgG1) to Human c-Met
Human
ELISA Flo IF IHC WB
Unconjugated
Anti-c-Met Antibody (aa276-325) LS-C199258
Immunofluorescence of A549 cells, using MET Antibody. The sample on the right was incubated with synthetic peptide.

Rabbit Polyclonal (IgG) to Human c-Met
Human
IF Peptide-ELISA
Unconjugated
Anti-c-Met Antibody (aa1361-1379) LS-C25603

Rabbit Polyclonal (IgG) to Mouse c-Met
Mouse, Rat
IP WB
Unconjugated
Anti-c-Met Antibody (phospho-Tyr1003) LS-C37359

Rabbit Monoclonal (IgG) to Human c-Met
Mouse, Human
ELISA WB
Unconjugated
Anti-c-Met Antibody (Tyr1003, clone SP59) LS-C210322
Immunohistochemistry of Human Breast Carcinoma stained with anti-c-Met (Paired 1003) antibody
Immunohistochemistry of Human Colon stained with anti-c-Met (Paired 1003) antibody

Rabbit Monoclonal [clone SP59] (IgG) to Human c-Met
Human
IHC IHC-P
Unconjugated
Anti-c-Met Antibody LS-C124098

Rabbit Polyclonal (IgG) to Human c-Met
Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
IHC
Unconjugated
Anti-c-Met Antibody (Tyr1234/Tyr1235) LS-C130723

Rabbit Monoclonal (IgG) to Human c-Met
Human
WB
Unconjugated
Anti-c-Met Antibody LS-C330774
Western blot analysis of extracts of various cells.

Rabbit Monoclonal (IgG) to Human c-Met
Human
WB
Unconjugated
Anti-c-Met Antibody (phospho-Tyr1003) LS-C416510
Western blot of c-Met phosphorylation expression in HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

Rabbit Polyclonal to Human c-Met
Mouse, Rat, Human
ICC IF IHC WB
Unconjugated
Anti-c-Met Antibody (phospho-Tyr1003) LS-C381530

Rabbit Polyclonal (IgG) to Human c-Met
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
Anti-c-Met Antibody (phospho-Tyr1003) LS-C357180
Immunohistochemistry of paraffin-embedded human colon carcinoma tissue, using c-Met (Phospho-Tyr1003) antibody.
Immunofluorescence of HepG2 cells, using c-Met (Phospho-Tyr1003) antibody.

Rabbit Polyclonal to Human c-Met
Mouse, Human
IF IHC IHC-P WB
Unconjugated
Anti-c-Met Antibody LS-C308966

Mouse Polyclonal (IgG) to Human c-Met
Human
WB
Unconjugated
Anti-c-Met Antibody (Tyr1234/Tyr1235, Agarose) LS-C130724

Rabbit Monoclonal (IgG) to Human c-Met
Mouse, Rat, Human
IP
Agarose Conjugated
Anti-c-Met Antibody LS-C499316
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA013714LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA013714LA01HU at dilution of 1:100

Rabbit Polyclonal (IgG) to Human c-Met
Human
ELISA IF IHC
Unconjugated

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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