c-Kit / CD117

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

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Products

ELISA Kits (31)

Type

Cell-Based Phosphorylation (3)

Custom (5)

Sandwich (20)

Sandwich CLIA (3)

Target

c-Kit / CD117 (31)

Reactivity

Human (15)

Mouse (9)

Rat (2)

Chicken (2)

Dog (1)

Monkey (1)

Pig (1)

Porcine (1)

Rabbit (1)

Sheep (1)

Format

12 x 8-Well Microstrips (3)

96-Well Microplate (8)

96-Well Strip Plate (20)

Publications

No (31)

Sample Type

Adherent Cell Cultures (3)

Cell Culture Supernatants (6)

Cell Lysates (4)

Plasma (19)

Serum (19)

Tissue Homogenates (5)

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Mouse/Human/Rat Phospho-c-Kit / CD117 (Tyr721) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1552

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human Phospho-c-Kit / CD117 (Tyr703) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1182

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Human c-Kit / CD117 (Sandwich ELISA) ELISA Kit - LS-F11883

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

3.12 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$685

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Rat c-Kit / CD117 (Sandwich ELISA) ELISA Kit - LS-F49274

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Monkey c-Kit / CD117 (Sandwich ELISA) ELISA Kit - LS-F48192

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Mouse c-Kit / CD117 (Sandwich ELISA) ELISA Kit - LS-F56328

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse/Human Phospho-c-Kit / CD117 (Tyr936) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1181

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Chicken c-Kit / CD117 (Sandwich ELISA) ELISA Kit - LS-F48188

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Sheep c-Kit / CD117 (Sandwich ELISA) ELISA Kit - LS-F48189

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Sheep

Range:

0.391 - 25 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$760

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Porcine c-Kit / CD117 (Sandwich ELISA) ELISA Kit - LS-F48190

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Rabbit c-Kit / CD117 (Sandwich ELISA) ELISA Kit - LS-F48191

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Mouse c-Kit / CD117 (CLIA) ELISA Kit - LS-F30958

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Pig c-Kit / CD117 (Custom ELISA) ELISA Kit - LS-F13796

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Chicken c-Kit / CD117 (Custom ELISA) ELISA Kit - LS-F13797

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$929

Select

Dog c-Kit / CD117 (Custom ELISA) ELISA Kit - LS-F13799

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Dog

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$929

Select

Bovine c-Kit / CD117 (Custom ELISA) ELISA Kit - LS-F13798

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Human c-Kit / CD117 (Sandwich ELISA) ELISA Kit - LS-F24400

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

780 - 50000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$717

Select

Human c-Kit / CD117 (CLIA) ELISA Kit - LS-F29844

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Human c-Kit / CD117 (Sandwich ELISA) ELISA Kit - LS-F2708

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$795

Select

Human c-Kit / CD117 (Sandwich ELISA) ELISA Kit - LS-F2972

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$795

Select

Mouse c-Kit / CD117 (Sandwich ELISA) ELISA Kit - LS-F21450

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Mouse c-Kit / CD117 (Sandwich ELISA) ELISA Kit - LS-F39788

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum

Price:

1 Plate/$795

Select

Human c-Kit / CD117 (Sandwich ELISA) ELISA Kit - LS-F22745

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Human c-Kit / CD117 (CLIA) ELISA Kit - LS-F25956

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

41.15 - 30000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$968

Select

Human c-Kit / CD117 (Sandwich ELISA) ELISA Kit - LS-F37054

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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