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C/EBP Alpha / CEBPA

CCAAT/enhancer binding protein (C/EBP), alpha

This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons.

Gene Name: CCAAT/enhancer binding protein (C/EBP), alpha
Synonyms: CEBPA, C/EBP alpha, C/EBP-alpha, CEBP
Target Sequences: NM_004364 NP_004355.2 P49715

Publications (1)

1
CCAAT/enhancer binding proteins alpha and beta regulate the tumor necrosis factor receptor 1 gene promoter. Bristol JA, Morrison TE, Kenney SC. Molecular immunology. 2009 46:2706-13. (WB, IP) [PubMed:19523687] [PMC:PMC2724677]

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Proteins (7)
Over-Expression Cell Culture Supernatant (1)
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C/EBP Alpha / CEBPA (7)
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Myc-DDK (Flag) (2)
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Supernatant (1)
C/EBP Alpha / CEBPA Protein - 12.5% SDS-PAGE of human CEBPA stained with Coomassie Blue
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Wheat Germ Extract
GST
65.8 kDa
2 µg/$439
C/EBP Alpha / CEBPA Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
37.4 kDa
100 µg/$494
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E. coli
His, N-Terminal
37.4 kDa
50 µg/$419
C/EBP Alpha / CEBPA Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
37.4 kDa
20 µg/$150
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HEK 293 Cells
His, N-Terminal
~38 kDa
100 µg/$298
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HEK 293 Cells
His, N-Terminal
~38 kDa
200 µl/$283
C/EBP Alpha / CEBPA Protein
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E. coli
His
100 µg/$317; 500 µg/$526; 20 µg/$245
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).