c-CBL

Cbl proto-oncogene, E3 ubiquitin protein ligase

Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

c-CBL (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His-GST (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human c-CBL Protein (Recombinant GST) (Full Length) - LS-G27760

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

126 kDa

Price:

10 µg/$479; 25 µg/$670

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Human c-CBL Protein (Recombinant His-GST) (aa558-816) - LS-G25547

Source:

E. coli

Tag:

His-GST

Molecular Weight:

57.8 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human c-CBL Protein (Recombinant GST, N-terminus) (aa736-835) - LS-G58005

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human c-CBL Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66752

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

99.5 kDa

Price:

20 µg/$1,107

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Human c-CBL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78423

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

99.5 kDa

Price:

20 µg/$215

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c-CBL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100472

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

99.5 kDa

Price:

100 µg/$710

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