BUB1B / BubR1

BUB1 mitotic checkpoint serine/threonine kinase B

Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.

☰ Filters

Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

BUB1B / BubR1 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

Select

Human BUB1B / BubR1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67694

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

119.3 kDa

Price:

20 µg/$1,107

Select

Human BUB1B / BubR1 Protein (Recombinant GST, N-terminus) (aa1-130) - LS-G57936

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human BUB1B / BubR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80499

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

119.3 kDa

Price:

20 µg/$150

Select

Human BUB1B / BubR1 Protein (Recombinant GST) (Full Length) - LS-G27667

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

141.24 kDa

Price:

10 µg/$479; 25 µg/$670

Select

BUB1B / BubR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118720

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

119.3 kDa

Price:

100 µg/$494

Viewing 1-5 of 5 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.