BUB1

BUB1 mitotic checkpoint serine/threonine kinase

Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.

☰ Filters

Products

Antibodies (45)

Proteins (5)

Type

Over-Expression Lysate (2)

Primary (45)

Recombinant (3)

Target

BUB1 (50)

Reactivity

Human (45)

Mouse (14)

Rat (4)

Application

IHC (21)

IHC-P (6)

WB (34)

Flo (2)

ELISA (22)

ICC (3)

IF (5)

IP (5)

Peptide-ELISA (2)

Host

rabbit (38)

mouse (7)

Product Group

IHCPlus (2)

Isotype

IgG (31)

IgG1 (5)

IgG1,k (2)

Clonality

monoclonal mc (7)

polyclonal pc (38)

Clone

14H5 (3)

1A11C7 (1)

4C3-4C9 (1)

P8.14H5.1H1 (1)

Format

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (2)

Unconjugated (32)

Epitope

aa1043-1073 (7)

220-300 aa, Internal (1)

750-830 aa, Internal (1)

aa1-30 (1)

aa1-50 (1)

aa251-300 (1)

aa281-419 (1)

aa731-1085 (1)

aa769-818 (1)

Publications

No (49)

Yes (1)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

Select

IHC-plus™ BUB1 Antibody LS-B2108

(4.0) Rating

Antibody:

BUB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

Select

BUB1 Antibody (aa251-300) LS-C118685

(4.0) Rating

(1) Publication(s)

Antibody:

BUB1 Rabbit anti-Human Polyclonal (aa251-300) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

Human BUB1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80179

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

122.2 kDa

Price:

20 µg/$150

Select

BUB1 Antibody (aa1-30) LS-C156894

Antibody:

BUB1 Rabbit anti-Human Polyclonal (aa1-30) Antibody

Reactivity:

Human

Applications:

Flo, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

IHC-plus™ BUB1 Antibody (aa769-818) LS-B11453

(4.0) Rating

Antibody:

BUB1 Rabbit anti-Human Polyclonal (aa769-818) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

BUB1 Antibody (aa281-419, clone 14H5) LS-C18935

Antibody:

BUB1 Mouse anti-Human Monoclonal (aa281-419) (14H5) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IP, WB

Format:

Unconjugated

Price:

100 µg/$574

Select

BUB1 Antibody (clone 1A11C7) LS-C682394

Antibody:

BUB1 Mouse anti-Human Monoclonal (1A11C7) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

Unconjugated

Price:

100 µl/$459

Select

BUB1 Antibody (clone 4C3-4C9) LS-C196778

Antibody:

BUB1 Mouse anti-Human Monoclonal (4C3-4C9) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

Select

BUB1 Antibody (aa1-50) LS-C287268

Antibody:

BUB1 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$520

Select

BUB1 Antibody (clone 14H5) LS-C82213

Antibody:

BUB1 Mouse anti-Human Monoclonal (14H5) Antibody

Reactivity:

Human

Applications:

ICC, IF, IP

Format:

Unconjugated

Price:

0.1 ml/$482

Select

BUB1 Antibody (aa1043-1073) LS-C326965

Antibody:

BUB1 Rabbit anti-Human Polyclonal (aa1043-1073) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

BUB1 Antibody (aa1043-1073, Biotin) LS-C275679

Antibody:

BUB1 Rabbit anti-Human Polyclonal (aa1043-1073) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

BUB1 Antibody (aa1043-1073, FITC) LS-C275680

Antibody:

BUB1 Rabbit anti-Human Polyclonal (aa1043-1073) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

BUB1 Antibody (aa1043-1073, PE) LS-C275682

Antibody:

BUB1 Rabbit anti-Human Polyclonal (aa1043-1073) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

BUB1 Antibody (aa1043-1073, APC) LS-C275678

Antibody:

BUB1 Rabbit anti-Human Polyclonal (aa1043-1073) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

BUB1 Antibody (aa1043-1073, Azide-free, HRP) LS-C275681

Antibody:

BUB1 Rabbit anti-Human Polyclonal (aa1043-1073) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• PE
• APC
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • PE
  • APC
  • HRP, Azide-free

Select

BUB1 Antibody LS-C659227

Antibody:

BUB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

BUB1 Antibody (clone P8.14H5.1H1) LS-C137473

Antibody:

BUB1 Mouse anti-Human Monoclonal (P8.14H5.1H1) Antibody

Reactivity:

Human

Applications:

IF, IP, WB

Format:

Unconjugated

Price:

100 µg/$375

Select

BUB1 Antibody (clone 14H5) LS-C179697

Antibody:

BUB1 Mouse anti-Human Monoclonal (14H5) Antibody

Reactivity:

Human

Applications:

ICC, IP, WB

Format:

Unconjugated

Price:

100 µg/$392

Select

BUB1 Antibody LS-C677324

Antibody:

BUB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

BUB1 Antibody (aa1043-1073) LS-C101148

Antibody:

BUB1 Rabbit anti-Human Polyclonal (aa1043-1073) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

BUB1 Antibody (220-300 aa, Internal) LS-C382335

Antibody:

BUB1 Rabbit anti-Human Polyclonal (220-300 aa, Internal) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

BUB1 Antibody LS-C764949

Antibody:

BUB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

BUB1 Antibody LS-C822461

Antibody:

BUB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

100 µg/$357

Select

BUB1 Antibody LS-C192708

Antibody:

BUB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

Viewing 1-25 of 50 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.