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BTN3A1 / CD277

butyrophilin, subfamily 3, member A1

Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.

Gene Name: butyrophilin, subfamily 3, member A1
Synonyms: BTN3A1, BT3.1, CD277 antigen, BTF5, CD277
Target Sequences: NM_007048 NP_008979.3 O00481

Publications (2)

1
Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on V?9Vd2 T cell activation. Gu S, Sachleben JR, Boughter CT, Nawrocka WI, Borowska MT, Tarrasch JT, Skiniotis G, Roux B, Adams EJ. Proceedings of the National Academy of Sciences of the United States of America. 2017 August;114:E7311-E7320. (Human) [Full Text Article] [PubMed:28807997] [PMC:PMC5584448] Related Antibodies: LS-C319905.
2
Regulation of Human ?d T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters. Rhodes DA, Chen HC, Williamson JC, Hill A, Yuan J, Smith S, Rhodes H, Trowsdale J, Lehner PJ, Herrmann T, Eberl M. Frontiers in immunology. 2018 April;9:662. [Full Text Article] [PubMed:29670629] [PMC:PMC5893821]

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).