BTK

Bruton agammaglobulinemia tyrosine kinase

Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.

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Proteins (12)

Type

Over-Expression Lysate (2)

Recombinant (10)

Target

BTK (12)

Publications

No (12)

Tag

10His, N-terminus (1)

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (2)

His,C-terminus (1)

His-GST (2)

Myc-DDK (Flag) (3)

Species

Human (10)

Rat (1)

Source

293T Cells (1)

Baculovirus (2)

E. coli (3)

HEK 293 Cells (2)

Sf9 Cells (1)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (2)

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Human BTK Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G22827

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

78.1 kD

Price:

1 mg/$1,607; 100 µg/$469; 20 µg/$349

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Human BTK Protein (Recombinant His-GST) (aa396-659) - LS-G14467

Source:

E. coli

Tag:

His-GST

Molecular Weight:

57.9 kDa

Price:

10 µg/$287; 50 µg/$477; 100 µg/$762; 200 µg/$952; 1 mg/$2,083; 500 µg/$1,613; 5 mg/$3,333; 2 mg/$2,272

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BTK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123416

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76.1 kDa

Price:

100 µg/$710

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Human BTK Protein (Recombinant 10His, N-terminus) (Full Length) - LS-G136831

Source:

Baculovirus

Tag:

10His, N-terminus

Molecular Weight:

78.3 kDa

Price:

100 µg/$810; 20 µg/$387; 1 mg/$1,678

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Human BTK Protein (Recombinant His,C-terminus) - LS-G142323

Source:

Sf9 Cells

Tag:

His,C-terminus

Molecular Weight:

76 kDa

Price:

20 µg/$677

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Rat BTK Protein (Recombinant His-GST) (aa1-168) - LS-G24551

Source:

E. coli

Tag:

His-GST

Molecular Weight:

49.7 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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Human BTK Protein (Recombinant GST) (Full Length) - LS-G27665

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

98.12 kDa

Price:

2 µg/$439

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Human BTK Protein (Recombinant GST, N-terminus) (aa100-189) - LS-G57929

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human BTK Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67233

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76.1 kDa

Price:

20 µg/$1,107

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Human BTK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79391

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76.1 kDa

Price:

20 µg/$215

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Human BTK Protein (Recombinant His) (Met1-Ser659) - LS-G98517

Source:

Baculovirus

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

77.8 kDa

Price:

50 µg/$707

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Human BTK Protein (Recombinant His) (aa185-299) - LS-G141132

Source:

E. coli

Sequence Length:

114 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

12.65 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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