BTK

Bruton agammaglobulinemia tyrosine kinase

Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.

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ELISA Kits (10)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Custom (1)

Sandwich (7)

Target

BTK (10)

Reactivity

Human (5)

Mouse (5)

Rat (3)

Chicken (1)

Format

96-Well Microplate (2)

96-Well Strip Plate (8)

Publications

No (10)

Sample Type

Adherent Cell Cultures (2)

Cell Lysates (3)

Plasma (4)

Serum (4)

Tissue Homogenates (5)

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Human BTK (Sandwich ELISA) ELISA Kit - LS-F10964

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human BTK (Sandwich ELISA) ELISA Kit - LS-F5728

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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Mouse BTK (Sandwich ELISA) ELISA Kit - LS-F10965

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Mouse/Human/Rat Phospho-BTK (Tyr223) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1072

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Chicken BTK (Custom ELISA) ELISA Kit - LS-F18804

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$929

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Mouse BTK (Sandwich ELISA) ELISA Kit - LS-F25333

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$818

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Mouse BTK (Sandwich ELISA) ELISA Kit - LS-F35747

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human BTK (Sandwich ELISA) ELISA Kit - LS-F35743

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse/Human/Rat BTK (Cell-Based ELISA) ELISA Kit - LS-F1835

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

Select

Rat BTK (Sandwich ELISA) ELISA Kit - LS-F9744

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$856

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